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Literature summary extracted from

  • Veyron-Churlet, R.; Molle, V.; Taylor, R.C.; Brown, A.K.; Besra, G.S.; Zanella-Cleon, I.; Fuetterer, K.; Kremer, L.
    The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue (2009), J. Biol. Chem., 284, 6414-6424.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.180 gene fabH, overexpression of His-tagged wild-type and mutant FabHs in Mycobacterium bovis strain BCG Mycobacterium tuberculosis

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.180 mapping of the Thr45 phosphorylation site on the mtFabH crystal structure, overview Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.180 T45A the mutant exhibits slightly decreased transacylation, malonyl-AcpM decarboxylation, and condensing activities compared to the wild-type protein Mycobacterium tuberculosis
2.3.1.180 T45D the mutant exhibits markedly decreased transacylation, malonyl-AcpM decarboxylation, and condensing activities compared to the wild-type protein Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 additional information Mycobacterium tuberculosis FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview ?
-
?
2.3.1.180 additional information Mycobacterium tuberculosis H37Rv FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Mycobacterium tuberculosis P9WNG3 gene fabH
-
2.3.1.180 Mycobacterium tuberculosis H37Rv P9WNG3 gene fabH
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.3.1.180 phosphoprotein FabH is efficiently phosphorylated in vitro exclusively on Thr45 by several mycobacterial Ser/Thr protein kinases, particularly by PknF and PknA, as well as in vivo in mycobacteria, mass spectrometric analysis, overview. Mapping of the Thr45 phosphorylation site on the FabH crystal structure Mycobacterium tuberculosis

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.180 recombinant His-tagged wild-type and mutant FabHs from Mycobacterium bovis strain BCG by nickel affinity chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
Mycobacterium tuberculosis 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP Mycobacterium tuberculosis 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
Mycobacterium tuberculosis H37Rv 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP Mycobacterium tuberculosis H37Rv 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
-
?
2.3.1.180 additional information FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview Mycobacterium tuberculosis ?
-
?
2.3.1.180 additional information FabH is regulated by Ser/Thr protein kinase-dependent phosphorylation at Thr45, overview Mycobacterium tuberculosis H37Rv ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 beta-ketoacyl-ACP synthase III
-
Mycobacterium tuberculosis
2.3.1.180 beta-ketoacyl-acyl carrier protein synthase III
-
Mycobacterium tuberculosis
2.3.1.180 FabH
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.180 37
-
condensation and decarboxylation assays at Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.180 7
-
condensation assay at Mycobacterium tuberculosis
2.3.1.180 7.5
-
decarboxylation assay at Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.3.1.180 physiological function FabH links FAS-I and FAS-II catalyzing the condensation of FAS-I-derived acyl-CoAs with malonyl-ACP. FabH represents a potential regulatory key point of the mycolic acid pathway Mycobacterium tuberculosis