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Literature summary extracted from

  • Yasuda, S.; Kai, M.; Imai, S.; Takeishi, K.; Taketomi, A.; Toyota, M.; Kanoh, H.; Sakane, F.
    Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization (2009), J. Biol. Chem., 284, 29559-29570.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.107 G392D activity of the mutant is less than 1% of the wild type enzyme Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Homo sapiens Q86XP1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.107 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 ATP + 1,2-diacylglycerol
-
 Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.107 DGKeta1 isoform Homo sapiens
2.7.1.107 DGKeta2 isoform Homo sapiens
2.7.1.107 diacylglycerol kinase eta isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.107 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.107 malfunction small interfering RNA-dependent knockdown of diacylglycerol kinase eta impairs the Ras/B-Raf/C-Raf/MEK/ERK pathway activated by epidermal growth factor in HeLa cells and inhibits cell proliferation Homo sapiens
2.7.1.107 physiological function overexpression of DGKeta1 can activate the Ras/B-Raf/C-Raf/MEK/ERK pathway in a DGK activity-independent manner, suggesting that DGKeta serves as a scaffold/adaptor protein, DGKeta activates C-Raf but not B-Raf Homo sapiens