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Literature summary extracted from

  • Luka, Z.; Mudd, S.H.; Wagner, C.
    Glycine N-methyltransferase and regulation of S-adenosylmethionine levels (2009), J. Biol. Chem., 284, 22507-22511.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.20 glucagon GNMT activity is induced by glucagon Mus musculus
2.1.1.20 glucagon GNMT activity is induced by glucagon Homo sapiens
2.1.1.20 glucagon GNMT activity is induced by glucagon Sus scrofa
2.1.1.20 glucagon GNMT activity is induced by glucagon Oryctolagus cuniculus
2.1.1.20 glucagon GNMT activity is induced by glucagon Danio rerio
2.1.1.20 glucagon GNMT activity is induced by glucagon Rattus norvegicus
2.1.1.20 Vitamin A GNMT activity is induced by vitamin A Mus musculus
2.1.1.20 Vitamin A GNMT activity is induced by vitamin A Homo sapiens
2.1.1.20 Vitamin A GNMT activity is induced by vitamin A Sus scrofa
2.1.1.20 Vitamin A GNMT activity is induced by vitamin A Oryctolagus cuniculus
2.1.1.20 Vitamin A GNMT activity is induced by vitamin A Danio rerio
2.1.1.20 Vitamin A GNMT activity is induced by vitamin A Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.20 expressed in Escherichia coli Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate
-
 Danio rerio
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate
-
 Homo sapiens
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate
-
 Mus musculus
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate
-
 Oryctolagus cuniculus
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate
-
 Rattus norvegicus
2.1.1.20 5-Methyltetrahydrofolate pentaglutamate
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.20 cytosol
-
 Mus musculus 5829
-
2.1.1.20 cytosol
-
 Homo sapiens 5829
-
2.1.1.20 cytosol
-
 Sus scrofa 5829
-
2.1.1.20 cytosol
-
 Oryctolagus cuniculus 5829
-
2.1.1.20 cytosol
-
 Danio rerio 5829
-
2.1.1.20 cytosol
-
 Rattus norvegicus 5829
-
2.1.1.20 nucleus presence in liver nuclei Mus musculus 5634
-
2.1.1.20 nucleus presence in liver nuclei Homo sapiens 5634
-
2.1.1.20 nucleus presence in liver nuclei Sus scrofa 5634
-
2.1.1.20 nucleus presence in liver nuclei Oryctolagus cuniculus 5634
-
2.1.1.20 nucleus presence in liver nuclei Danio rerio 5634
-
2.1.1.20 nucleus presence in liver nuclei Rattus norvegicus 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.1.1.20 32500
-
 4 * 32500 Mus musculus
2.1.1.20 32500
-
 4 * 32500 Homo sapiens
2.1.1.20 32500
-
 4 * 32500 Sus scrofa
2.1.1.20 32500
-
 4 * 32500 Oryctolagus cuniculus
2.1.1.20 32500
-
 4 * 32500 Danio rerio
2.1.1.20 32500
-
 4 * 32500 Rattus norvegicus
2.1.1.20 130000
-
-
 Mus musculus
2.1.1.20 130000
-
-
 Homo sapiens
2.1.1.20 130000
-
-
 Sus scrofa
2.1.1.20 130000
-
-
 Oryctolagus cuniculus
2.1.1.20 130000
-
-
 Danio rerio
2.1.1.20 130000
-
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.20 Danio rerio
-
-
-
2.1.1.20 Homo sapiens
-
-
-
2.1.1.20 Mus musculus
-
-
-
2.1.1.20 Oryctolagus cuniculus
-
-
-
2.1.1.20 Rattus norvegicus P13255
-
-
2.1.1.20 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.20 cerebellar Purkinje cell
-
 Mus musculus
-
2.1.1.20 cerebellar Purkinje cell
-
 Homo sapiens
-
2.1.1.20 cerebellar Purkinje cell
-
 Oryctolagus cuniculus
-
2.1.1.20 cerebellar Purkinje cell
-
 Rattus norvegicus
-
2.1.1.20 cerebral cortical neuron
-
 Mus musculus
-
2.1.1.20 cerebral cortical neuron
-
 Homo sapiens
-
2.1.1.20 cerebral cortical neuron
-
 Oryctolagus cuniculus
-
2.1.1.20 cerebral cortical neuron
-
 Rattus norvegicus
-
2.1.1.20 intestinal mucosa
-
 Mus musculus
-
2.1.1.20 intestinal mucosa
-
 Homo sapiens
-
2.1.1.20 intestinal mucosa
-
 Oryctolagus cuniculus
-
2.1.1.20 intestinal mucosa
-
 Rattus norvegicus
-
2.1.1.20 liver
-
 Mus musculus
-
2.1.1.20 liver
-
 Homo sapiens
-
2.1.1.20 liver
-
 Sus scrofa
-
2.1.1.20 liver
-
 Oryctolagus cuniculus
-
2.1.1.20 liver
-
 Danio rerio
-
2.1.1.20 liver
-
 Rattus norvegicus
-
2.1.1.20 pancreas
-
 Mus musculus
-
2.1.1.20 pancreas
-
 Homo sapiens
-
2.1.1.20 pancreas
-
 Sus scrofa
-
2.1.1.20 pancreas
-
 Oryctolagus cuniculus
-
2.1.1.20 pancreas
-
 Rattus norvegicus
-
2.1.1.20 prostate gland
-
 Mus musculus
-
2.1.1.20 prostate gland
-
 Homo sapiens
-
2.1.1.20 prostate gland
-
 Sus scrofa
-
2.1.1.20 prostate gland
-
 Oryctolagus cuniculus
-
2.1.1.20 prostate gland
-
 Rattus norvegicus
-
2.1.1.20 renal proximal tubule
-
 Mus musculus
-
2.1.1.20 renal proximal tubule
-
 Homo sapiens
-
2.1.1.20 renal proximal tubule
-
 Oryctolagus cuniculus
-
2.1.1.20 renal proximal tubule
-
 Rattus norvegicus
-
2.1.1.20 submandibular gland
-
 Mus musculus
-
2.1.1.20 submandibular gland
-
 Homo sapiens
-
2.1.1.20 submandibular gland
-
 Oryctolagus cuniculus
-
2.1.1.20 submandibular gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Mus musculus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Homo sapiens S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Sus scrofa S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Oryctolagus cuniculus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Danio rerio S-adenosyl-L-homocysteine + N-methylglycine
-
 ?
2.1.1.20 S-adenosyl-L-methionine + glycine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + N-methylglycine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.1.1.20 homotetramer 4 * 32500 Mus musculus
2.1.1.20 homotetramer 4 * 32500 Homo sapiens
2.1.1.20 homotetramer 4 * 32500 Sus scrofa
2.1.1.20 homotetramer 4 * 32500 Oryctolagus cuniculus
2.1.1.20 homotetramer 4 * 32500 Danio rerio
2.1.1.20 homotetramer 4 * 32500 Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
2.1.1.20 glycine methyltransferase
-
 Mus musculus
2.1.1.20 glycine methyltransferase
-
 Homo sapiens
2.1.1.20 glycine methyltransferase
-
 Sus scrofa
2.1.1.20 glycine methyltransferase
-
 Oryctolagus cuniculus
2.1.1.20 glycine methyltransferase
-
 Danio rerio
2.1.1.20 glycine methyltransferase
-
 Rattus norvegicus
2.1.1.20 GNMT
-
 Mus musculus
2.1.1.20 GNMT
-
 Homo sapiens
2.1.1.20 GNMT
-
 Sus scrofa
2.1.1.20 GNMT
-
 Oryctolagus cuniculus
2.1.1.20 GNMT
-
 Danio rerio
2.1.1.20 GNMT
-
 Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.20 9
-
-
 Mus musculus
2.1.1.20 9
-
-
 Homo sapiens
2.1.1.20 9
-
-
 Sus scrofa
2.1.1.20 9
-
-
 Oryctolagus cuniculus
2.1.1.20 9
-
-
 Danio rerio
2.1.1.20 9
-
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.20 0.0013
-
 native enzyme Rattus norvegicus 5-Methyltetrahydrofolate pentaglutamate
2.1.1.20 0.59
-
 recombinant enzyme Rattus norvegicus 5-Methyltetrahydrofolate pentaglutamate

Expression

EC Number Organism Comment Expression
2.1.1.20 Mus musculus GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue down
2.1.1.20 Homo sapiens GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue down
2.1.1.20 Sus scrofa GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue down
2.1.1.20 Oryctolagus cuniculus GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue down
2.1.1.20 Danio rerio GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue down
2.1.1.20 Rattus norvegicus GNMT expression is down-regulated or even completely blocked in liver and prostate tumor tissue down

General Information

EC Number General Information Comment Organism
2.1.1.20 malfunction Gnmt knockout mice develop fatty livers when they have increased S-adenosyl-L-methionine Mus musculus
2.1.1.20 metabolism GNMT is involved in both hepatic methyl group and one-carbon metabolism Mus musculus
2.1.1.20 metabolism GNMT is involved in both hepatic methyl group and one-carbon metabolism Homo sapiens
2.1.1.20 metabolism GNMT is involved in both hepatic methyl group and one-carbon metabolism Sus scrofa
2.1.1.20 metabolism GNMT is involved in both hepatic methyl group and one-carbon metabolism Oryctolagus cuniculus
2.1.1.20 metabolism GNMT is involved in both hepatic methyl group and one-carbon metabolism Danio rerio
2.1.1.20 metabolism GNMT is involved in both hepatic methyl group and one-carbon metabolism Rattus norvegicus
2.1.1.20 physiological function GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels Mus musculus
2.1.1.20 physiological function GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels Homo sapiens
2.1.1.20 physiological function GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels Sus scrofa
2.1.1.20 physiological function GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels Oryctolagus cuniculus
2.1.1.20 physiological function GNMT plays a major role in maintaining normal S-adenosyl-L-methionine levels Rattus norvegicus