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Literature summary extracted from

  • Perrine, C.L.; Ganguli, A.; Wu, P.; Bertozzi, C.R.; Fritz, T.A.; Raman, J.; Tabak, L.A.; Gerken, T.A.
    Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2 (2009), J. Biol. Chem., 284, 20387-20397.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.41 soluble isozyme ppGalNAc T1 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.41 additional information Homo sapiens UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases transfer GalNAc from UDP-GalNAc to the Ser and Thr residues of polypeptide acceptors, and initiate and regulate mucin-type O-glycosylation ?
-
 ?
2.4.1.41 additional information Bos taurus UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases transfer GalNAc from UDP-GalNAc to the Ser and Thr residues of polypeptide acceptors, and initiate and regulate mucin-type O-glycosylation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Bos taurus
-
 isozyme ppGalNAc T1
-
2.4.1.41 Homo sapiens
-
 isozymes ppGalNAc T2 and ppGalNAc T10
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 additional information UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases transfer GalNAc from UDP-GalNAc to the Ser and Thr residues of polypeptide acceptors, and initiate and regulate mucin-type O-glycosylation Homo sapiens ?
-
 ?
2.4.1.41 additional information UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases transfer GalNAc from UDP-GalNAc to the Ser and Thr residues of polypeptide acceptors, and initiate and regulate mucin-type O-glycosylation Bos taurus ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + GAGAPGPTPGPAGAGK optimal isozyme ppGalNAc T2 peptide substrate Homo sapiens UDP + GAGAPGP-(N-acetyl-D-galactosaminylT)-PGPAGAGK
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + osteopontin isozyme ppGalNAc T10 prefers previously glycosylated peptides as substrates, ppGalNAc T10 exhibits a single large preference for Ser/Thr-O-GalNAc at the +1, C-terminal, position relative to the Ser or Thr acceptor site Homo sapiens UDP + N-acetyl-D-galactosaminyl-osteopontin
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide usage of random peptide substrates, overview. Isozyme substrate specificities, amino acid residue enhancement factors for ppGalNAc T isozymes are obtained from random peptide substrates, detailed overview Homo sapiens UDP + N-acetyl-D-galactosaminyl-polypeptide product analysis by NMR and mass spectrometry ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + polypeptide usage of random peptide substrates, overview. Isozyme substrate specificity, amino acid residue enhancement factors for the ppGalNAc T isozyme are obtained from random peptide substrates, detailed overview Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide product analysis by NMR and mass spectrometry ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.41 glycopeptide-preferring polypeptide GalNAc transferase 10
-
 Homo sapiens
2.4.1.41 glycopeptide-preferring polypeptide GalNAc transferase 10
-
 Bos taurus
2.4.1.41 More the enzyme belongs to the large family of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases, ppGalNAc Ts Homo sapiens
2.4.1.41 More the enzyme belongs to the large family of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases, ppGalNAc Ts Bos taurus
2.4.1.41 ppGalNAc T1
-
 Bos taurus
2.4.1.41 ppGalNAc T10
-
 Homo sapiens
2.4.1.41 ppGalNAc T2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.41 37
-
 assay at Homo sapiens
2.4.1.41 37
-
 assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.41 7.8
-
 assay at Homo sapiens
2.4.1.41 7.8
-
 assay at Bos taurus