Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jian, W.; Lee, S.H.; Williams, M.V.; Blair, I.A.
    5-Lipoxygenase-mediated endogenous DNA damage (2009), J. Biol. Chem., 284, 16799-16807.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.34 additional information calcium ionophore A23187 increases concentrations of 5(S)-hydroxy-6,8,11,14-(E,Z,Z,Z)-eicosatetraenoic acid from 0.07 to 45.5 pmol/10000000 cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.34 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.34 CESS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.34 arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.34 5-lipoxygenase
-
 Homo sapiens
1.13.11.34 5-LO
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.13.11.34 physiological function 5-lipoxygenase-derived lipid hydroperoxide is responsible for endogenous DNA-adduct formation. 5-lipoxygenase is responsible for the generation of the heptanone-etheno-2'-deoxyguanosine DNA-adduct in CESS cells Homo sapiens