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Literature summary extracted from

  • Cheng, D.; Iqbal, J.; Devenny, J.; Chu, C.H.; Chen, L.; Dong, J.; Seethala, R.; Keim, W.J.; Azzara, A.V.; Lawrence, R.M.; Pelleymounter, M.A.; Hussain, M.M.
    Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption (2008), J. Biol. Chem., 283, 29802-29811.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.20 expressed in a baculovirus expression system Mus musculus
2.3.1.20 expressed in a baculovirus expression system Homo sapiens
2.3.1.20 expressed in a baculovirus expression system Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.20 XP620 dihydrothiopyrancarboxamide Homo sapiens
2.3.1.20 XP620 dihydrothiopyrancarboxamide Mus musculus
2.3.1.20 XP620 dihydrothiopyrancarboxamide Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Homo sapiens
-
-
-
2.3.1.20 Mus musculus
-
-
-
2.3.1.20 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.20 intestine
-
 Mus musculus
-
2.3.1.20 intestine
-
 Homo sapiens
-
2.3.1.20 intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.20 acyl-CoA + hexadecanol
-
 Homo sapiens CoA + ?
-
 ?
2.3.1.20 oleoyl-CoA + 1,2-dioleoyl-sn-glycerol
-
 Mus musculus CoA + triolein
-
 ?
2.3.1.20 oleoyl-CoA + 1,2-dioleoyl-sn-glycerol
-
 Homo sapiens CoA + triolein
-
 ?
2.3.1.20 oleoyl-CoA + 1,2-dioleoyl-sn-glycerol
-
 Rattus norvegicus CoA + triolein
-
 ?
2.3.1.20 oleoyl-CoA + sn-2-monooleoylglycerol
-
 Mus musculus CoA + 1,2-dioleoyl-sn-glycerol
-
 ?
2.3.1.20 oleoyl-CoA + sn-2-monooleoylglycerol
-
 Homo sapiens CoA + 1,2-dioleoyl-sn-glycerol
-
 ?
2.3.1.20 oleoyl-CoA + sn-2-monooleoylglycerol
-
 Rattus norvegicus CoA + 1,2-dioleoyl-sn-glycerol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.20 acyl coenzyme A:diacylglycerol acyltransferase 1
-
 Mus musculus
2.3.1.20 acyl coenzyme A:diacylglycerol acyltransferase 1
-
 Homo sapiens
2.3.1.20 acyl coenzyme A:diacylglycerol acyltransferase 1
-
 Rattus norvegicus
2.3.1.20 acyl coenzyme A:diacylglycerol acyltransferase 2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.20 additional information
-
 IC50 above 0.03 mM with 1,2-dioleoyl-sn-glycerol or sn-2-monooleoylglycerol as substrate Homo sapiens XP620
2.3.1.20 0.0000014
-
 substrate: 1-hexadecanol Mus musculus XP620
2.3.1.20 0.0000027
-
 substrate: sn-2-monooleoylglycerol Mus musculus XP620
2.3.1.20 0.0000029
-
 substrate: sn-2-monooleoylglycerol Rattus norvegicus XP620
2.3.1.20 0.0000166
-
 substrate: sn-2-monooleoylglycerol Homo sapiens XP620
2.3.1.20 0.0000233
-
 substrate: 1-hexadecanol Homo sapiens XP620
2.3.1.20 0.000123
-
 substrate: 1,2-dioleoyl-sn-glycerol Mus musculus XP620
2.3.1.20 0.000176
-
 substrate: 1,2-dioleoyl-sn-glycerol Rattus norvegicus XP620
2.3.1.20 0.001499
-
 substrate: 1,2-dioleoyl-sn-glycerol Homo sapiens XP620