EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.48 | laminar shear stress | laminar shear stress stimulates acetylation of histones 3 and 4 at the region of the eNOS promoter SSRE and extends 3' toward the eNOS coding region. Laminar shear stress induces p300 binding to p65 and leads to increase of p300 histone acetyltransferase activity by 2.5fold and to increase of acetylation of p65, but not of p50 acetylation, overview | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.48 | curcumin | increase in eNOS mRNA, caused by shear stress, is completely blocked by p300 small interfering RNA; increase in eNOS mRNA, caused by shear stress, is completely blocked by pharmacological inhibition of p300/HAT activity with curcumin | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.48 | chromatin | - |
Homo sapiens | 785 | - |
2.3.1.48 | nucleus | - |
Homo sapiens | 5634 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.48 | acetyl-CoA + histone H3 | Homo sapiens | - |
CoA + acetylhistone H3 | - |
? | |
2.3.1.48 | acetyl-CoA + histone H4 | Homo sapiens | - |
CoA + acetylhistone H4 | - |
? | |
2.3.1.48 | acetyl-CoA + p50 protein | Homo sapiens | acetylation of p50 by p300 independent of shear stress | CoA + acetyl-p50 protein | - |
? | |
2.3.1.48 | acetyl-CoA + p65 protein | Homo sapiens | acetylation of p65 by p300 during translocation into the nuclei in response to shear stress | CoA + acetyl-p65 protein | - |
? | |
2.3.1.48 | additional information | Homo sapiens | increase in eNOS mRNA, caused by shear stress, is completely blocked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering RNA | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.48 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.48 | umbilical vein endothelial cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.48 | acetyl-CoA + histone H3 | - |
Homo sapiens | CoA + acetylhistone H3 | - |
? | |
2.3.1.48 | acetyl-CoA + histone H4 | - |
Homo sapiens | CoA + acetylhistone H4 | - |
? | |
2.3.1.48 | acetyl-CoA + histone H4 | substrate is H4 peptide | Homo sapiens | CoA + acetylhistone H4 | - |
? | |
2.3.1.48 | acetyl-CoA + p50 protein | acetylation of p50 by p300 independent of shear stress | Homo sapiens | CoA + acetyl-p50 protein | - |
? | |
2.3.1.48 | acetyl-CoA + p50 protein | acetylation of histones H4 at the site of SSRE within the eNOS promoter | Homo sapiens | CoA + acetyl-p50 protein | - |
? | |
2.3.1.48 | acetyl-CoA + p65 protein | acetylation of p65 by p300 during translocation into the nuclei in response to shear stress | Homo sapiens | CoA + acetyl-p65 protein | - |
? | |
2.3.1.48 | acetyl-CoA + p65 protein | acetylation of histones H3 at the site of SSRE within the eNOS promoter | Homo sapiens | CoA + acetyl-p65 protein | - |
? | |
2.3.1.48 | additional information | increase in eNOS mRNA, caused by shear stress, is completely blocked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering RNA | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.48 | HAT | - |
Homo sapiens |
2.3.1.48 | p300 | - |
Homo sapiens |
2.3.1.48 | p300 histone acetyltransferase | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.48 | acetyl-CoA | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.48 | physiological function | p300 plays a key role in NFkappaB subunit acetylation | Homo sapiens |