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Literature summary extracted from

  • Scott, D.R.; Marcus, E.A.; Wen, Y.; Singh, S.; Feng, J.; Sachs, G.
    Cytoplasmic histidine kinase (HP0244)-regulated assembly of urease with UreI, a channel for urea and its metabolites, CO2, NH3, and NH4+, is necessary for acid survival of Helicobacter pylori (2010), J. Bacteriol., 192, 94-103.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.13.3 cytoplasm
-
 Helicobacter pylori 5737
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.13.3 Helicobacter pylori
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.13.3 HP0165
-
 Helicobacter pylori
2.7.13.3 HP0244
-
 Helicobacter pylori
2.7.13.3 sensor histidine kinase
-
 Helicobacter pylori

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.13.3 ATP
-
 Helicobacter pylori

General Information

EC Number General Information Comment Organism
2.7.13.3 malfunction HP0244 deletion abolishes urease activation and assembly, impairs cytoplasmic and periplasmic pH homeostasis, and depolarizes the cells, with an about 7-log loss of survival at pH 2.5, even in 10 mM urea Helicobacter pylori
2.7.13.3 physiological function HP0244 is required for inner membrane assembly of UreA, UreB, and UreE and for urease activity Helicobacter pylori