Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Pribat, A.; Jeanguenin, L.; Lara-Nunez, A.; Ziemak, M.J.; Hyde, J.E.; de Crecy-Lagard, V.; Hanson, A.D.
    6-Pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme dihydroneopterin aldolase in diverse bacteria (2009), J. Bacteriol., 191, 4158-4165.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.2.25 expressed in Escherichia coli folB deletant cells Escherichia coli
4.2.3.12 His-tagged version expressed in Escherichia coli BL21(DE3) Clostridium botulinum
4.2.3.12 His-tagged version expressed in Escherichia coli BL21(DE3) Leptospira interrogans

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.2.3.12 Zn2+
-
Clostridium botulinum
4.2.3.12 Zn2+
-
Leptospira interrogans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.2.25 7,8-dihydroneopterin Escherichia coli
-
6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
-
?
4.1.2.25 7,8-dihydroneopterin Escherichia coli MG1655
-
6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
-
?

Organism

EC Number Organism UniProt Comment Textmining
4.1.2.25 Escherichia coli
-
-
-
4.1.2.25 Escherichia coli MG1655
-
-
-
4.2.3.12 Clostridium botulinum
-
-
-
4.2.3.12 Leptospira interrogans
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.3.12 immobilized metal ion affinity chromatography (Ni2+) Clostridium botulinum
4.2.3.12 immobilized metal ion affinity chromatography (Ni2+) Leptospira interrogans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.2.25 7,8-dihydroneopterin
-
Escherichia coli 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
-
?
4.1.2.25 7,8-dihydroneopterin
-
Escherichia coli MG1655 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde
-
?
4.2.3.12 dihydroneopterin triphosphate
-
Clostridium botulinum 6-hydroxymethyldihydropterin + triphosphate + ?
-
?
4.2.3.12 dihydroneopterin triphosphate
-
Leptospira interrogans 6-hydroxymethyldihydropterin + triphosphate + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
4.1.2.25 FolB
-
Escherichia coli
4.2.3.12 6-pyruvoyltetrahydropterin synthase paralog
-
Clostridium botulinum
4.2.3.12 6-pyruvoyltetrahydropterin synthase paralog
-
Leptospira interrogans
4.2.3.12 6-pyruvoyltetrahydropterin synthase-like protein
-
Clostridium botulinum
4.2.3.12 6-pyruvoyltetrahydropterin synthase-like protein
-
Leptospira interrogans
4.2.3.12 PTPS-III
-
Clostridium botulinum
4.2.3.12 PTPS-III
-
Leptospira interrogans

General Information

EC Number General Information Comment Organism
4.1.2.25 malfunction 6-pyruvoyltetrahydropterin synthase paralogs with an active-site glutamate (designated PTPS-III proteins) can functionally replace FolB in vivo Escherichia coli