EC Number | Cloned (Comment) | Organism |
---|---|---|
4.1.2.25 | expressed in Escherichia coli folB deletant cells | Escherichia coli |
4.2.3.12 | His-tagged version expressed in Escherichia coli BL21(DE3) | Clostridium botulinum |
4.2.3.12 | His-tagged version expressed in Escherichia coli BL21(DE3) | Leptospira interrogans |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.2.3.12 | Zn2+ | - |
Clostridium botulinum | |
4.2.3.12 | Zn2+ | - |
Leptospira interrogans |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.2.25 | 7,8-dihydroneopterin | Escherichia coli | - |
6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
? | |
4.1.2.25 | 7,8-dihydroneopterin | Escherichia coli MG1655 | - |
6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.2.25 | Escherichia coli | - |
- |
- |
4.1.2.25 | Escherichia coli MG1655 | - |
- |
- |
4.2.3.12 | Clostridium botulinum | - |
- |
- |
4.2.3.12 | Leptospira interrogans | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.2.3.12 | immobilized metal ion affinity chromatography (Ni2+) | Clostridium botulinum |
4.2.3.12 | immobilized metal ion affinity chromatography (Ni2+) | Leptospira interrogans |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.2.25 | 7,8-dihydroneopterin | - |
Escherichia coli | 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
? | |
4.1.2.25 | 7,8-dihydroneopterin | - |
Escherichia coli MG1655 | 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde | - |
? | |
4.2.3.12 | dihydroneopterin triphosphate | - |
Clostridium botulinum | 6-hydroxymethyldihydropterin + triphosphate + ? | - |
? | |
4.2.3.12 | dihydroneopterin triphosphate | - |
Leptospira interrogans | 6-hydroxymethyldihydropterin + triphosphate + ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.2.25 | FolB | - |
Escherichia coli |
4.2.3.12 | 6-pyruvoyltetrahydropterin synthase paralog | - |
Clostridium botulinum |
4.2.3.12 | 6-pyruvoyltetrahydropterin synthase paralog | - |
Leptospira interrogans |
4.2.3.12 | 6-pyruvoyltetrahydropterin synthase-like protein | - |
Clostridium botulinum |
4.2.3.12 | 6-pyruvoyltetrahydropterin synthase-like protein | - |
Leptospira interrogans |
4.2.3.12 | PTPS-III | - |
Clostridium botulinum |
4.2.3.12 | PTPS-III | - |
Leptospira interrogans |
EC Number | General Information | Comment | Organism |
---|---|---|---|
4.1.2.25 | malfunction | 6-pyruvoyltetrahydropterin synthase paralogs with an active-site glutamate (designated PTPS-III proteins) can functionally replace FolB in vivo | Escherichia coli |