Literature summary extracted from

Maidhof, H.; Reinicke, B.; Blumel, P.; Berger-Bachi, B.; Labischinski, H.
femA, Which encodes a factor essential for expression of methicillin resistance, affects glycine content of peptidoglycan in methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains (1991), J. Bacteriol., 173, 3507-3513.

Protein Variants

EC Number	Protein Variants	Comment	Organism
2.3.2.17	additional information	analysis of several related methicillin-resistant, methicillin-susceptible, and TnS51 insertionally inactivated femA mutants. All mutants have a reduced peptidoglycan glycine content compared to that of related femA parent strains. Additional effects of femA inactivation and the subsequent decrease in peptidoglycan-associated glycine are reduced digestion of peptidoglycan by recombinant lysostaphin, unaltered digestion of peptidoglycan by Chalaropsis B-muramidase, reduced cell wall turnover, reduced whole-cell autolysis, and increased sensitivity towards beta-lactam antibiotics. The peptidoglycan-associated glycine content of a femA::Tn5Sl methicillin-susceptible strain is restored concomitantly with the methicillin resistance to a level almost equal to that of its femA4 methicillin-resistant parent strain by introduction of a plasmid encoding femA	Staphylococcus aureus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.2.17	Staphylococcus aureus	-	-	-

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Release 2023.1 (January 2023)