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Literature summary extracted from

  • Murakami, R.; Fujita, Y.; Kizuka, M.; Kagawa, T.; Muramatsu, Y.; Miyakoshi, S.; Takatsu, T.; Inukai, M.
    A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity (2008), J. Antibiot., 61, 537-544.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.8.13 medicine translocase I is a target of antibiotics Staphylococcus aureus
2.7.8.13 medicine translocase I is a target of antibiotics Enterococcus faecalis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.8.13 A-94964
-
 Enterococcus faecalis
2.7.8.13 A-94964
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate Staphylococcus aureus
-
 UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate Enterococcus faecalis
-
 UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.13 Enterococcus faecalis
-
-
-
2.7.8.13 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
 Staphylococcus aureus UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?
2.7.8.13 UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate
-
 Enterococcus faecalis UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 ?
2.7.8.13 UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate inhibitory assay Staphylococcus aureus UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
-
 ?
2.7.8.13 UDP-MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala + undecaprenyl phosphate inhibitory assay Enterococcus faecalis UMP + MurNAc-L-Ala-gamma-D-Glu-m-DAP-[Nepsilon-dansyl]-D-Ala-D-Ala-diphosphoundecaprenol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.13 phospho-N-acetylmuramyl-pentapeptide translocase
-
 Staphylococcus aureus
2.7.8.13 phospho-N-acetylmuramyl-pentapeptide translocase
-
 Enterococcus faecalis
2.7.8.13 translocase I
-
 Staphylococcus aureus
2.7.8.13 translocase I
-
 Enterococcus faecalis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.8.13 22
-
 inhibitory assay at room temperature Staphylococcus aureus
2.7.8.13 22
-
 inhibitory assay at room temperature Enterococcus faecalis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.8.13 7.5
-
 inhibitory assay Staphylococcus aureus
2.7.8.13 7.5
-
 inhibitory assay Enterococcus faecalis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.8.13 1.1
-
 MIC 100 microg/ml against Staphylococcus aureus Staphylococcus aureus A-94964
2.7.8.13 1.1
-
 MIC 50 microg/ml against Enterococcus faecalis Enterococcus faecalis A-94964

General Information

EC Number General Information Comment Organism
2.7.8.13 physiological function translocase I is a key enzyme in peptidoglycan biosynthesis Staphylococcus aureus
2.7.8.13 physiological function translocase I is a key enzyme in peptidoglycan biosynthesis Enterococcus faecalis