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Literature summary extracted from
- A suite of activity-based probes for human cytochrome P450 enzymes (2009), J. Am. Chem. Soc., 131, 10692-10700.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.1 | anastrozole | increases labeling of P450 1A2 by probe 3 up to 175% of control values | Homo sapiens |  |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.14.1 | recombinant cDNA P450s coexpressed with cytochrome P450 reductase in insect cell microsomes | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.1 | 17alpha-ethynylestradiol | reactive intermediates of 17alpha-ethynylestradiol inactivate P450s in a NADPH-dependent mechanism-based manner by a combination of heme alkylation and apoprotein modification | Homo sapiens | |
| 1.14.14.1 | 8-methoxypsoralen | - |
Homo sapiens | |
| 1.14.14.1 | anastrozole | profiling inhibition of probe 1 labeling of P450 19A1, inhibits labeling of P450 2C9 by probe 5 | Homo sapiens | |
| 1.14.14.1 | formestane | profiling inhibition of probe 1 labeling of P450 19A1, decreases probe 5 labeling of P450 2C19 and 1 labeling of P450 3A4 | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.14.1 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.1 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.1 | liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.1 | additional information | reacts with activity-based proteins of varying chemical composition, quite distinct from their natural substrates | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.14.1 | aromatase | - |
Homo sapiens |
| 1.14.14.1 | P450 19A1 | - |
Homo sapiens |
| 1.14.14.1 | P450 1A1 | - |
Homo sapiens |
| 1.14.14.1 | P450 1A2 | - |
Homo sapiens |
| 1.14.14.1 | P450 1B1 | - |
Homo sapiens |
| 1.14.14.1 | P450 2A6 | - |
Homo sapiens |
| 1.14.14.1 | P450 2B6 | - |
Homo sapiens |
| 1.14.14.1 | P450 2C19 | - |
Homo sapiens |
| 1.14.14.1 | P450 2C9 | - |
Homo sapiens |
| 1.14.14.1 | P450 2D6 | - |
Homo sapiens |
| 1.14.14.1 | P450 2E1 | - |
Homo sapiens |
| 1.14.14.1 | P450 2J2 | - |
Homo sapiens |
| 1.14.14.1 | P450 3A4 | - |
Homo sapiens |
| 1.14.14.1 | P450 4A11 | - |
Homo sapiens |
| 1.14.14.1 | P450 4F2 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.1 | NADPH | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.14.14.1 | 0.00043 | - |
P450 19A1 | Homo sapiens | formestane | |
| 1.14.14.1 | 0.001 | - |
P450 19A1 | Homo sapiens | anastrozole | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.14.1 | physiological function | P450 1B1 is able to activate a broad spectrum of chemical carcinogens, including polycyclic hydrocarbons and heterocyclic and aromatic amines | Homo sapiens |
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