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Literature summary extracted from

  • Park, H.R.; Yoo, M.Y.; Seo, J.H.; Kim, I.S.; Kim, N.Y.; Kang, J.Y.; Cui, L.; Lee, C.S.; Lee, C.H.; Lee, H.S.
    Sesquiterpenoids isolated from the flower buds of Tussilago farfara L. inhibit diacylglycerol acyltransferase (2008), J. Agric. Food Chem., 56, 10493-10497.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.20 7beta-(3-ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone
-
 Homo sapiens
2.3.1.20 7beta-(3-ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone
-
 Rattus norvegicus
2.3.1.20 8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one
-
 Homo sapiens
2.3.1.20 8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one
-
 Rattus norvegicus
2.3.1.20 kurarinone
-
 Homo sapiens
2.3.1.20 kurarinone
-
 Rattus norvegicus
2.3.1.20 tussilagone
-
 Homo sapiens
2.3.1.20 tussilagone
-
 Rattus norvegicus
2.3.1.20 tussilagonone
-
 Homo sapiens
2.3.1.20 tussilagonone
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.20 microsome
-
 Homo sapiens
-
-
2.3.1.20 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.20 Homo sapiens
-
-
-
2.3.1.20 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.20 Hep-G2 cell
-
 Homo sapiens
-
2.3.1.20 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.20 oleoyl-CoA + sn-1,2-dioleoylglycerol
-
 Homo sapiens triolein + CoA
-
 ?
2.3.1.20 oleoyl-CoA + sn-1,2-dioleoylglycerol
-
 Rattus norvegicus triolein + CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.20 acyl CoA:diacylglycerol acyltransferase
-
 Homo sapiens
2.3.1.20 acyl CoA:diacylglycerol acyltransferase
-
 Rattus norvegicus
2.3.1.20 diacylglycerol acyltransferase
-
 Homo sapiens
2.3.1.20 diacylglycerol acyltransferase
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.20 additional information
-
 IC50 value for tussilagonone above 0.5 mM Homo sapiens additional information
2.3.1.20 0.0109
-
-
 Rattus norvegicus kurarinone
2.3.1.20 0.0188
-
-
 Rattus norvegicus tussilagone
2.3.1.20 0.0288
-
-
 Homo sapiens kurarinone
2.3.1.20 0.047
-
-
 Rattus norvegicus 7beta-(3-ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone
2.3.1.20 0.0491
-
-
 Homo sapiens tussilagone
2.3.1.20 0.0992
-
-
 Rattus norvegicus tussilagonone
2.3.1.20 0.1607
-
-
 Homo sapiens 7beta-(3-ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone
2.3.1.20 0.211
-
-
 Rattus norvegicus 8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one
2.3.1.20 0.2944
-
-
 Homo sapiens 8-angeloyloxy-3,4-epoxy-bisabola-7(14),10-dien-2-one