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Literature summary extracted from

  • Cappello, P.; Tomaino, B.; Chiarle, R.; Ceruti, P.; Novarino, A.; Castagnoli, C.; Migliorini, P.; Perconti, G.; Giallongo, A.; Milella, M.; Monsurro, V.; Barbi, S.; Scarpa, A.; Nistico, P.; Giovarelli, M.; Novelli, F.
    An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen (2009), Int. J. Cancer, 125, 639-648.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.1.11 medicine alpha-enolase is a pancreatic ductal adenocarcinoma-associated antigen Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.1.11 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.2.1.11 cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.1.11 2-phospho-D-glycerate Homo sapiens
-
 phosphoenolpyruvate + H2O
-
 r

Organism

EC Number Organism UniProt Comment Textmining
4.2.1.11 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.2.1.11 Ni2+-affinity column chromatography Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.1.11 CFPAC-1 cell
-
 Homo sapiens
-
4.2.1.11 K-562 cell
-
 Homo sapiens
-
4.2.1.11 MiaPaCa-2 cell
-
 Homo sapiens
-
4.2.1.11 PaCa-44 cell
-
 Homo sapiens
-
4.2.1.11 PANC-1 cell
-
 Homo sapiens
-
4.2.1.11 pancreatic ductal adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.1.11 2-phospho-D-glycerate
-
 Homo sapiens phosphoenolpyruvate + H2O
-
 r

Synonyms

EC Number Synonyms Comment Organism
4.2.1.11 alpha-enolase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.2.1.11 Homo sapiens alpha-enolase is overexpressed at both mRNA and protein levels in pancreatic ductal adenocarcinoma cells up

General Information

EC Number General Information Comment Organism
4.2.1.11 physiological function alpha-enolase is a glycolytic enzyme that also acts as a surface plasminogen receptor, alpha-enolase elicits a pancreatic ductal adenocarcinoma cell-specific, integrated humoral and cellular response Homo sapiens