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Literature summary extracted from

  • Krishnan-Natesan, S.; Chandrasekar, P.H.; Alangaden, G.J.; Manavathu, E.K.
    Molecular characterisation of cyp51A and cyp51B genes coding for P450 14alpha-lanosterol demethylases A (CYP51Ap) and B (CYP51Bp) from voriconazole-resistant laboratory isolates of Aspergillus flavus (2008), Int. J. Antimicrob. Agents, 32, 519-524.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.154
-
 Aspergillus flavus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.154 H399P/D411N CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent Aspergillus flavus
1.14.14.154 K197N CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent Aspergillus flavus
1.14.14.154 K197N/D282E/M288L CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent Aspergillus flavus
1.14.14.154 T454P/T486P CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent Aspergillus flavus
1.14.14.154 Y132N/T469S CYP51Ap mutant of voriconazole-resistant clinical isolate, shows higher minimum inhibitory concentration of voriconazole compared with the drug-susceptible parent Aspergillus flavus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 Amphotericin B
-
 Aspergillus flavus
1.14.14.154 itraconazole
-
 Aspergillus flavus
1.14.14.154 posaconazole
-
 Aspergillus flavus
1.14.14.154 ravuconazole
-
 Aspergillus flavus
1.14.14.154 voriconazole
-
 Aspergillus flavus

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Aspergillus flavus
-
 voriconazole-resistant clinical isolates and voriconazole-susceptible parent strain X26728
-

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 CYP51Ap
-
 Aspergillus flavus
1.14.14.154 CYP51Bp
-
 Aspergillus flavus
1.14.14.154 P450 14alpha-lanosterol demethylases A
-
 Aspergillus flavus
1.14.14.154 P450 14alpha-lanosterol demethylases B
-
 Aspergillus flavus