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Literature summary extracted from

  • Vandermoten, S.; Santini, S.; Haubruge, E.; Heuze, F.; Francis, F.; Brasseur, R.; Cusson, M.; Charloteaux, B.
    Structural features conferring dual geranyl/farnesyl diphosphate synthase activity to an aphid prenyltransferase (2009), Insect Biochem. Mol. Biol., 39, 707-716.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.1
-
 Acyrthosiphon pisum
2.5.1.10
-
 Acyrthosiphon pisum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.1 molecular dynamics simulations for wild-type and mutants Q107E, L110W, Q107F, Q107F/L110A, L110A Acyrthosiphon pisum
2.5.1.10 molecular dynamics simulations for wild-type and mutants Q107E, L110W, Q107F, Q107F/L110A, L110A Acyrthosiphon pisum

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.1 L110A complete loss of activity Acyrthosiphon pisum
2.5.1.1 L110W about 50% decrease in reaction rate, increase in production of geranyl diphosphate Acyrthosiphon pisum
2.5.1.1 Q107E increase in production of geranyl diphosphate Acyrthosiphon pisum
2.5.1.1 Q107F increase in production of farnesyl diphosphate Acyrthosiphon pisum
2.5.1.10 L110A complete loss of activity Acyrthosiphon pisum
2.5.1.10 L110W about 50% decrease in reaction rate, increase in production of geranyl diphosphate Acyrthosiphon pisum
2.5.1.10 Q107E increase in production of geranyl diphosphate Acyrthosiphon pisum
2.5.1.10 Q107F increase in production of farnesyl diphosphate Acyrthosiphon pisum

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.1 Acyrthosiphon pisum Q1X877 dual geranyl/farnesyl diphosphate synthase
-
2.5.1.10 Acyrthosiphon pisum Q1X877 dual geranyl/farnesyl diphosphate synthase
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.1 dimethylallyl diphosphate + isopentenyl diphosphate
-
 Acyrthosiphon pisum (E,E)-farnesyl diphosphate + geranyl diphosphate + diphosphate ratio geranyl diphosphate/farnesyl diphosphate is about 2:1 ?
2.5.1.10 dimethylallyl diphosphate + isopentenyl diphosphate
-
 Acyrthosiphon pisum (E,E)-farnesyl diphosphate + geranyl diphosphate + diphosphate ratio geranyl diphosphate/farnesyl diphosphate is about 2:1 ?