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Literature summary extracted from

  • Stiebritz, M.T.; Reiher, M.
    Theoretical study of dioxygen induced inhibition of [FeFe]-hydrogenase (2009), Inorg. Chem., 48, 7127-7140.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.12.99.6 industry inhibition by dioxygen is a major drawback for the application of [FeFe]-hydrogenase in hydrogen fuel production or as electrocatalysts for hydrogen oxidation in fuel cells Clostridium pasteurianum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.12.99.6 O2 the direct interaction of the [2Fe]H subsite with dioxygen is an exothermic and specific reaction in which O2 most favorably binds in an end-on manner to the distal iron. Irreversibility of dioxygen-induced enzyme inactivation by water release and degradation of the ligand environment of the H-cluster Clostridium pasteurianum

Organism

EC Number Organism UniProt Comment Textmining
1.12.99.6 Clostridium pasteurianum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.12.99.6 H2 + oxidized electron acceptor
-
Clostridium pasteurianum H+ + reduced electron acceptor
-
?

Synonyms

EC Number Synonyms Comment Organism
1.12.99.6 [FeFe]-hydrogenase
-
Clostridium pasteurianum