EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.4.1.221 | cell surface | OFUT1 may be a chaperone of Notch that is necessary for retaining Notch at the cell surface once it has traversed the secretory pathway | Drosophila sp. (in: flies) | 9986 | - |
2.4.1.221 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
2.4.1.221 | endoplasmic reticulum | OFUT1 may be a chaperone of Notch that is necessary for escorting Notch out of the endoplasmic reticulum | Drosophila sp. (in: flies) | 5783 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.221 | Cricetulus griseus | - |
- |
- |
2.4.1.221 | Drosophila sp. (in: flies) | - |
- |
- |
2.4.1.221 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.1.221 | CHO cell | - |
Cricetulus griseus | - |
2.4.1.221 | embryonic stem cell | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.221 | GDP-L-fucose + Notch | Pofut1 transfers fucose in the endoplasmic reticulum, transfers fucose to Ser or Thr residues of epidermal growth factor-like repeats | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.221 | O-fucosyltransferase 1 | - |
Cricetulus griseus |
2.4.1.221 | O-fucosyltransferase 1 | - |
Drosophila sp. (in: flies) |
2.4.1.221 | O-fucosyltransferase 1 | - |
Mus musculus |
2.4.1.221 | OFUT1 | - |
Drosophila sp. (in: flies) |
2.4.1.221 | Pofut1 | - |
Cricetulus griseus |
2.4.1.221 | Pofut1 | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.1.221 | malfunction | CHO cells lacking Pofut1 express Notch receptors on the cell surface at similar levels to wild-type cells | Cricetulus griseus |
2.4.1.221 | malfunction | deletion of Pofut1 leads to global defects in Notch signaling and death of mice at E9.5, with a phenotype consistent with inactivation of signaling by the four Notch receptors. Embryonic stem cells lacking Pofut1 express Notch receptors on the cell surface at similar levels to wild-type cells. In mouse somites, there is evidence of altered Notch trafficking in the absence of Pofut1, consistent with reduced cell surface expression | Mus musculus |