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Literature summary extracted from

  • Pesu, M.; Laurence, A.; Kishore, N.; Zwillich, S.H.; Chan, G.; O‘Shea, J.J.
    Therapeutic targeting of Janus kinases (2008), Immunol. Rev., 223, 132-142.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 additional information Tyk2 mutations are associated with autosomal recessive hyperimmunoglobulin E or JobÂ’s syndrome Homo sapiens
2.7.10.2 V617F JAK2 gain-of-function mutation underlying myeloproliferative diseases Mus musculus
2.7.10.2 V617F JAK2 gain-of-function mutation underlying myeloproliferative diseases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 CP-690,550 has nanomolar potency in in vitro JAK2 and JAK3 kinase assays Homo sapiens
2.7.10.2 CP-690,550 has nanomolar potency in in vitro JAK2 and JAK3 kinase assays Mus musculus
2.7.10.2 INCB18424 Incyte Homo sapiens
2.7.10.2 INCB18424 Incyte Mus musculus
2.7.10.2 XL019 Exelixis Homo sapiens
2.7.10.2 XL019 Exelixis Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.10.2 Mg2+ required for activity Mus musculus
2.7.10.2 Mg2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Mus musculus
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-
2.7.10.2 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.10.2 phosphoprotein Y785 and Y813 in JAK3 and JAK2 respectively are prominent sites of autophosphorylation Mus musculus
2.7.10.2 phosphoprotein Y785 and Y813 in JAK3 and JAK2 respectively are prominent sites of autophosphorylation Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Mus musculus ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 JAK2
-
 Mus musculus
2.7.10.2 JAK2
-
 Homo sapiens
2.7.10.2 Jak3
-
 Mus musculus
2.7.10.2 Jak3
-
 Homo sapiens
2.7.10.2 Janus kinase
-
 Mus musculus
2.7.10.2 Janus kinase
-
 Homo sapiens
2.7.10.2 Tyk2
-
 Mus musculus
2.7.10.2 Tyk2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.10.2 ATP
-
 Mus musculus
2.7.10.2 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.10.2 malfunction mutations of JAK3 may be a cause of severe combined immunodeficiency Homo sapiens
2.7.10.2 malfunction mutations of JAK3 may be a cause of severe combined immunodeficiency, JAK3 knockout mice have a profound reduction in thymic progenitor cells and reduced ability to reconstitute T cell development, in the periphery, CD8+ T and NK cells are severely reduced. JAK3- (and gamma chain) deficient mice also have severely defective B cell development, deficiency of JAK1 and JAK2 is lethal Mus musculus
2.7.10.2 physiological function JAK3 associates with the common gamma chain cytokine receptor, Tyk2 is involved in signaling by type I interferons, interleukin-12 and interleukin-23 Mus musculus
2.7.10.2 physiological function JAK3 associates with the common gamma chain cytokine receptor, Tyk2 is involved in signaling by type I interferons, interleukin-12 and interleukin-23 Homo sapiens