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Literature summary extracted from
- Regulation of Salmonella enterica pathogenicity island 1 (SPI-1) by DNA adenine methylation (2009), Genetics, 184, 637-649.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.1.1.72 | additional information | Salmonella enterica | Dam-dependent regulation of secretion of pathogenicity island 1 is transmitted via transcriptional regulator HilD | ? | - |
? |  |
| 2.1.1.72 | S-adenosyl-L-methionine + DNA adenine | Salmonella enterica | - |
S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.1.1.72 | Salmonella enterica | - |
serovar typhimurium | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.1.1.72 | additional information | Dam-dependent regulation of secretion of pathogenicity island 1 is transmitted via transcriptional regulator HilD | Salmonella enterica | ? | - |
? | |
| 2.1.1.72 | S-adenosyl-L-methionine + DNA adenine | - |
Salmonella enterica | S-adenosyl-L-homocysteine + DNA 6-methyladenine | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.1.1.72 | Dam | - |
Salmonella enterica |
| 2.1.1.72 | DNA adenine methyltransferase | - |
Salmonella enterica |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.1.1.72 | malfunction | Dam negative mutants contain lowered levels of the secretion of pathogenicity island 1 transcriptional regulators HilA, HilC, HilD, and InvF. Dam negative mutants with the intestinal epithelium have been tentatively correlated with reduced secretion of pathogenicity island 1 | Salmonella enterica |
| 2.1.1.72 | physiological function | Dam methylation 1 may control transcription of a postranscriptional regulator of hilD expression, Dam methylation regulates the level and the stability of hilD mRNA | Salmonella enterica |
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