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Literature summary extracted from

  • Van Craeyveld, E.; Lievens, J.; Jacobs, F.; Feng, Y.; Snoeys, J.; De Geest, B.
    Apolipoprotein A-I and lecithin:cholesterol acyltransferase transfer induce cholesterol unloading in complex atherosclerotic lesions (2009), Gene Ther., 16, 757-765.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 apolipoprotein A-I
-
 Oryctolagus cuniculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.43 overexpression of LCAT in rabbit hepatocytes Oryctolagus cuniculus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.43 additional information hepatocyte-directed adenoviral gene transfer of LCAT or apolipoprotein A-I to LDLr+/- rabbits with 0.15% cholesterol-diet-induced hyperlipidemia increases the HDL cholesterol in these rabbits, intimal lesions in organs of the LDL+/- heterozygous rabbits, overview Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 additional information Oryctolagus cuniculus increased HDL cholesterol after LCAT lecithin-cholesterol acyltransfer activity inhibits progression of atherosclerosis and induces cholesterol unloading in complex lesions in rabbits, overview ?
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Oryctolagus cuniculus
-
 New Zealand white rabbits
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information increased HDL cholesterol after LCAT lecithin-cholesterol acyltransfer activity inhibits progression of atherosclerosis and induces cholesterol unloading in complex lesions in rabbits, overview Oryctolagus cuniculus ?
-
 ?
2.3.1.43 additional information LCAT catalyzes the transacylation of a fatty acid at the sn-2 position of phosphatidylcholine preferentially to the free 3beta-hydroxyl group of cholesterol in HDL and to a lesser extent in LDL particles Oryctolagus cuniculus ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 lecithin:cholesterol acyltransferase
-
 Oryctolagus cuniculus