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Literature summary extracted from

  • Lau, C.; Niere, M.; Ziegler, M.
    The NMN/NaMN adenylyltransferase (NMNAT) protein family (2009), Front. Biosci., 14, 410-431.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.7.7.1
-
 Homo sapiens
2.7.7.1
-
 Escherichia coli
2.7.7.18
-
 Homo sapiens
2.7.7.18
-
 Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.1 NAD+ product inhibition Homo sapiens
2.7.7.1 nicotinic acid adenine dinucleotide product inhibition Homo sapiens
2.7.7.18 NAD+ product inhibition Homo sapiens
2.7.7.18 nicotinic acid adenine dinucleotide product inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.1 0.0017
-
 ATP
-
 Escherichia coli
2.7.7.1 0.015
-
 nicotinic acid mononucleotide
-
 Homo sapiens
2.7.7.1 0.021
-
 nicotinamide mononucleotide range 0.021-0.032 mM Homo sapiens
2.7.7.1 0.0304
-
 reduced nicotinamide mononucleotide
-
 Homo sapiens
2.7.7.1 0.07
-
 NAD+
-
 Homo sapiens
2.7.7.1 0.073
-
 NAD+
-
 Saccharomyces cerevisiae
2.7.7.1 0.083
-
 diphosphate
-
 Saccharomyces cerevisiae
2.7.7.1 0.104
-
 ATP
-
 Saccharomyces cerevisiae
2.7.7.1 0.17
-
 nicotinamide mononucleotide
-
 Saccharomyces cerevisiae
2.7.7.1 0.7
-
 nicotinamide mononucleotide
-
 Escherichia coli
2.7.7.1 1.119
-
 diphosphate
-
 Homo sapiens
2.7.7.18 0.0017
-
 ATP
-
 Escherichia coli
2.7.7.18 0.015
-
 nicotinic acid mononucleotide
-
 Homo sapiens
2.7.7.18 0.021
-
 nicotinamide mononucleotide range 0.021-0.032 mM Homo sapiens
2.7.7.18 0.0304
-
 reduced nicotinamide nucleotide
-
 Homo sapiens
2.7.7.18 0.07
-
 NAD+
-
 Homo sapiens
2.7.7.18 0.073
-
 NAD+
-
 Saccharomyces cerevisiae
2.7.7.18 0.083
-
 diphosphate
-
 Saccharomyces cerevisiae
2.7.7.18 0.104
-
 ATP
-
 Saccharomyces cerevisiae
2.7.7.18 0.17
-
 nicotinamide mononucleotide
-
 Saccharomyces cerevisiae
2.7.7.18 0.7
-
 nicotinamide mononucleotide
-
 Escherichia coli
2.7.7.18 1.119
-
 diphosphate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.1 cytoplasm
-
 Homo sapiens 5737
-
2.7.7.1 mitochondrion
-
 Homo sapiens 5739
-
2.7.7.1 nucleus
-
 Saccharomyces cerevisiae 5634
-
2.7.7.18 cytoplasm
-
 Homo sapiens 5737
-
2.7.7.18 mitochondrion
-
 Homo sapiens 5739
-
2.7.7.18 nucleus
-
 Saccharomyces cerevisiae 5634
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.7.1 24500
-
 x * 24500, calculated: 24528 Arabidopsis thaliana
2.7.7.1 34439
-
 4 * 34439, calculated Homo sapiens
2.7.7.1 48000
-
 4 * 48000, calculated: 45859 Saccharomyces cerevisiae
2.7.7.18 24500
-
 x * 24500, calculated: 24528 Arabidopsis thaliana
2.7.7.18 34439
-
 4 * 34439, calculated Homo sapiens
2.7.7.18 48000
-
 4 * 48000, calculated: 45859 Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.1 Arabidopsis thaliana
-
-
-
2.7.7.1 Escherichia coli P0A752
-
-
2.7.7.1 Homo sapiens Q96T66
-
-
2.7.7.1 Saccharomyces cerevisiae P53204
-
-
2.7.7.18 Arabidopsis thaliana
-
-
-
2.7.7.18 Escherichia coli P0A752
-
-
2.7.7.18 Homo sapiens Q96T66
-
-
2.7.7.18 Saccharomyces cerevisiae P53204
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.1 brain
-
 Homo sapiens
-
2.7.7.1 cotyledon
-
 Arabidopsis thaliana
-
2.7.7.1 gametophyte
-
 Arabidopsis thaliana
-
2.7.7.1 heart
-
 Homo sapiens
-
2.7.7.1 muscle
-
 Homo sapiens
-
2.7.7.1 root
-
 Arabidopsis thaliana
-
2.7.7.18 brain
-
 Homo sapiens
-
2.7.7.18 cotyledon
-
 Arabidopsis thaliana
-
2.7.7.18 gametophyte
-
 Arabidopsis thaliana
-
2.7.7.18 heart
-
 Homo sapiens
-
2.7.7.18 muscle
-
 Homo sapiens
-
2.7.7.18 root
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Arabidopsis thaliana diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Saccharomyces cerevisiae diphosphate + NAD+
-
 r
2.7.7.1 ATP + nicotinamide ribonucleotide
-
 Escherichia coli diphosphate + NAD+
-
 r
2.7.7.1 nicotinic acid mononucleotide + ATP
-
 Arabidopsis thaliana nicotinic acid adenine dinucleotide + diphosphate
-
 r
2.7.7.1 nicotinic acid mononucleotide + ATP
-
 Escherichia coli nicotinic acid adenine dinucleotide + diphosphate
-
 r
2.7.7.1 nicotinic acid mononucleotide + ATP activity observed with dATP, ITP Saccharomyces cerevisiae nicotinic acid adenine dinucleotide + diphosphate
-
 r
2.7.7.1 nicotinic acid mononucleotide + ATP activity observed with GTP, ITP Homo sapiens nicotinic acid adenine dinucleotide + diphosphate
-
 r
2.7.7.18 ATP + nicotinamide ribonucleotide
-
 Arabidopsis thaliana diphosphate + NAD+
-
 r
2.7.7.18 ATP + nicotinamide ribonucleotide
-
 Homo sapiens diphosphate + NAD+
-
 r
2.7.7.18 ATP + nicotinamide ribonucleotide
-
 Saccharomyces cerevisiae diphosphate + NAD+
-
 r
2.7.7.18 ATP + nicotinamide ribonucleotide
-
 Escherichia coli diphosphate + NAD+
-
 r
2.7.7.18 ATP + reduced nicotinamide nucleotide
-
 Homo sapiens diphosphate + NADH + H+
-
 ?
2.7.7.18 nicotinic acid mononucleotide + ATP
-
 Arabidopsis thaliana nicotinic acid adenine dinucleotide + diphosphate
-
 r
2.7.7.18 nicotinic acid mononucleotide + ATP
-
 Escherichia coli nicotinic acid adenine dinucleotide + diphosphate
-
 r
2.7.7.18 nicotinic acid mononucleotide + ATP activity observed with dATP, ITP Saccharomyces cerevisiae nicotinic acid adenine dinucleotide + diphosphate
-
 r
2.7.7.18 nicotinic acid mononucleotide + ATP activity observed with GTP, ITP Homo sapiens nicotinic acid adenine dinucleotide + diphosphate
-
 r

Subunits

EC Number Subunits Comment Organism
2.7.7.1 ? x * 24500, calculated: 24528 Arabidopsis thaliana
2.7.7.1 homotetramer 4 * 34439, calculated Homo sapiens
2.7.7.1 homotetramer 4 * 48000, calculated: 45859 Saccharomyces cerevisiae
2.7.7.1 monomer
-
 Escherichia coli
2.7.7.18 ? x * 24500, calculated: 24528 Arabidopsis thaliana
2.7.7.18 homotetramer 4 * 34439, calculated Homo sapiens
2.7.7.18 homotetramer 4 * 48000, calculated: 45859 Saccharomyces cerevisiae
2.7.7.18 monomer
-
 Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.7.7.1 nadD
-
 Escherichia coli
2.7.7.1 NMN/NaMN adenylyltransferase
-
 Arabidopsis thaliana
2.7.7.1 NMN/NaMN adenylyltransferase
-
 Escherichia coli
2.7.7.1 NMN/NaMN adenylyltransferase 2
-
 Saccharomyces cerevisiae
2.7.7.1 NMN/NaMN adenylyltransferase 3
-
 Homo sapiens
2.7.7.18 nadD
-
 Escherichia coli
2.7.7.18 NMN/NaMN adenylyltransferase
-
 Arabidopsis thaliana
2.7.7.18 NMN/NaMN adenylyltransferase
-
 Escherichia coli
2.7.7.18 NMN/NaMN adenylyltransferase 2
-
 Saccharomyces cerevisiae
2.7.7.18 NMN/NaMN adenylyltransferase 3
-
 Homo sapiens