EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.43 | additional information | water samples from Balkan endemic nephropathy, BEN, villages from Serbia and Romania show higher LCAT inhibiting activity compared to deionised water and non-endemic water. Inhibitory effect of the organic compounds found in endemic water supplies can cause secondary LCAT deficiency and provide an ethiopathogenic basis for the development of BEN in the susceptible population, overview | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.43 | extracellular | - |
Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.43 | phosphatidylcholine + cholesterol | Homo sapiens | - |
cholesteryl ester + lysophosphatidylcholine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.43 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.43 | blood plasma | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.43 | phosphatidylcholine + cholesterol | - |
Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.43 | LCAT | - |
Homo sapiens |
2.3.1.43 | lecithin cholesterol acyltransferase | - |
Homo sapiens |
2.3.1.43 | plasma lecithin-cholesterol acyltransferase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.43 | malfunction | LCAT inhibition leads to the Balkan endemic nephropathy, BEN, chronic, slowly progressive renal disease, overview. Familial renal disease can develop secondary LCAT deficiency and associated lipid abnormalities | Homo sapiens |