BRENDA - Enzyme Database show

Effect of cadmium binding form on rabbit aminolevulinate dehydratase in high molecular weight fraction of rainbow trout liver

Jia, H.; Ren, H.; Endo, H.; Hayashi, T.; Fish. Sci. 76, 495-501 (2010)
No PubMed abstract available

Data extracted from this reference:

Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
4.2.1.24
Cd2+
inhibits enzymatic activity. High molecular weight fraction as well as metallothionein are involved in the detoxification of harmful heavy metals
Oncorhynchus mykiss
4.2.1.24
Cu2+
inhibits enzymatic activity. High molecular weight fraction as well as metallothionein are involved in the detoxification of harmful heavy metals
Oncorhynchus mykiss
4.2.1.24
Zn2+
inhibits enzymatic activity
Oncorhynchus mykiss
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Oncorhynchus mykiss
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
liver
-
Oncorhynchus mykiss
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
703782
Oncorhynchus mykiss
porphobilinogen + 2 H2O
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
4.2.1.24
37
-
assay at
Oncorhynchus mykiss
pH Range
EC Number
pH Minimum
pH Maximum
Commentary
Organism
4.2.1.24
7.6
8
enzyme activity is not inhibited when the pH is between 7.6 and 8.0, and enzyme activity is only inhibited by 1.3% at pH 8.2
Oncorhynchus mykiss
4.2.1.24
7.8
8
assay at
Oncorhynchus mykiss
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
4.2.1.24
Cd2+
inhibits enzymatic activity. High molecular weight fraction as well as metallothionein are involved in the detoxification of harmful heavy metals
Oncorhynchus mykiss
4.2.1.24
Cu2+
inhibits enzymatic activity. High molecular weight fraction as well as metallothionein are involved in the detoxification of harmful heavy metals
Oncorhynchus mykiss
4.2.1.24
Zn2+
inhibits enzymatic activity
Oncorhynchus mykiss
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
liver
-
Oncorhynchus mykiss
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
5-aminolevulinate + 5-aminolevulinate
-
703782
Oncorhynchus mykiss
porphobilinogen + 2 H2O
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
4.2.1.24
37
-
assay at
Oncorhynchus mykiss
pH Range (protein specific)
EC Number
pH Minimum
pH Maximum
Commentary
Organism
4.2.1.24
7.6
8
enzyme activity is not inhibited when the pH is between 7.6 and 8.0, and enzyme activity is only inhibited by 1.3% at pH 8.2
Oncorhynchus mykiss
4.2.1.24
7.8
8
assay at
Oncorhynchus mykiss