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Literature summary extracted from

  • Wriessnegger, T.; Sunga, A.J.; Cregg, J.M.; Daum, G.
    Identification of phosphatidylserine decarboxylases 1 and 2 from Pichia pastoris (2009), FEMS Yeast Res., 9, 911-922.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.1.65 mitochondrion isoform PSD1 Komagataella pastoris 5739
-

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.65 Komagataella pastoris
-
-
-
4.1.1.65 Komagataella pastoris GS115
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.65 Phosphatidyl-L-serine
-
 Komagataella pastoris Phosphatidylethanolamine + CO2
-
 ?
4.1.1.65 Phosphatidyl-L-serine
-
 Komagataella pastoris GS115 Phosphatidylethanolamine + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.65 PSD1 isoform Komagataella pastoris
4.1.1.65 Psd1p isoform Komagataella pastoris
4.1.1.65 PSD2 isoform Komagataella pastoris
4.1.1.65 Psd2p isoform Komagataella pastoris

General Information

EC Number General Information Comment Organism
4.1.1.65 malfunction deletion of isoform PSD1 causes loss of PSD activity in mitochondria, a severe growth defect on minimal media, and depletion of cellular and mitochondrial phosphatidylethanolamine levels. This defect cannot be compensated by Psd2p. In the homogenate of psd2DELTA, the PSD activity is only slightly reduced, whereas in psd1DELTA total PSD activity is only 25% of wild type Komagataella pastoris