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Literature summary extracted from

  • Marinus, M.G.; Casadesus, J.
    Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more (2009), FEMS Microbiol. Rev., 33, 488-503.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Brucella abortus the DNA target sequence is GANTC S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Caulobacter vibrioides the DNA target sequence is GANTC, CcrM is more active on hemimethylated than unmethylated DNA S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Escherichia coli the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Klebsiella pneumoniae the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Aeromonas hydrophila the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Salmonella enterica the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Vibrio cholerae serotype O1 the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Yersinia enterocolitica the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Aggregatibacter actinomycetemcomitans the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Campylobacter jejuni the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Pasteurella multocida the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.72 Aeromonas hydrophila
-
-
-
2.1.1.72 Aggregatibacter actinomycetemcomitans
-
-
-
2.1.1.72 Brucella abortus
-
-
-
2.1.1.72 Campylobacter jejuni
-
-
-
2.1.1.72 Caulobacter vibrioides
-
-
-
2.1.1.72 Escherichia coli
-
-
-
2.1.1.72 Klebsiella pneumoniae
-
-
-
2.1.1.72 Pasteurella multocida
-
-
-
2.1.1.72 Salmonella enterica
-
 serovar typhimurium
-
2.1.1.72 Vibrio cholerae serotype O1
-
-
-
2.1.1.72 Yersinia enterocolitica
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GANTC Brucella abortus S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GANTC, CcrM is more active on hemimethylated than unmethylated DNA Caulobacter vibrioides S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Klebsiella pneumoniae S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Aeromonas hydrophila S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Salmonella enterica S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Vibrio cholerae serotype O1 S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Yersinia enterocolitica S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Aggregatibacter actinomycetemcomitans S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Campylobacter jejuni S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the DNA target sequence is GATC, the natural substrate for the enzyme is hemimethylated DNA, where one strand is methylated and the other is not Pasteurella multocida S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.72 CcrM
-
 Caulobacter vibrioides
2.1.1.72 CcrM methylase
-
 Brucella abortus
2.1.1.72 Dam methylase
-
 Escherichia coli
2.1.1.72 Dam methylase
-
 Klebsiella pneumoniae
2.1.1.72 Dam methylase
-
 Aeromonas hydrophila
2.1.1.72 Dam methylase
-
 Salmonella enterica
2.1.1.72 Dam methylase
-
 Vibrio cholerae serotype O1
2.1.1.72 Dam methylase
-
 Yersinia enterocolitica
2.1.1.72 Dam methylase
-
 Aggregatibacter actinomycetemcomitans
2.1.1.72 Dam methylase
-
 Campylobacter jejuni
2.1.1.72 Dam methylase
-
 Pasteurella multocida
2.1.1.72 DNA adenine methyltransferase
-
 Escherichia coli
2.1.1.72 DNA adenine methyltransferase
-
 Brucella abortus
2.1.1.72 DNA adenine methyltransferase
-
 Klebsiella pneumoniae
2.1.1.72 DNA adenine methyltransferase
-
 Aeromonas hydrophila
2.1.1.72 DNA adenine methyltransferase
-
 Salmonella enterica
2.1.1.72 DNA adenine methyltransferase
-
 Caulobacter vibrioides
2.1.1.72 DNA adenine methyltransferase
-
 Vibrio cholerae serotype O1
2.1.1.72 DNA adenine methyltransferase
-
 Yersinia enterocolitica
2.1.1.72 DNA adenine methyltransferase
-
 Aggregatibacter actinomycetemcomitans
2.1.1.72 DNA adenine methyltransferase
-
 Campylobacter jejuni
2.1.1.72 DNA adenine methyltransferase
-
 Pasteurella multocida

General Information

EC Number General Information Comment Organism
2.1.1.72 malfunction a relevant defect of Yersinia enterocolitica Dam overproducers is enhanced invasion capacity, probably associated with transcriptional alterations in invasin genes inv and ail, and with changes in the composition of lipopolysaccharide O-antigen Yersinia enterocolitica
2.1.1.72 malfunction knockout of a putative DNA methyltransferase gene in Campylobacter jejuni causes reduced motility, aberrant flagellar appearance, and hyperadherence to epithelial cells, accompanied by reduced invasion Campylobacter jejuni
2.1.1.72 malfunction lack of Dam methylation causes partial attenuation upon intranasal or intraperitoneal inoculation of mice Klebsiella pneumoniae
2.1.1.72 malfunction mutants lacking Dam methylase are not viable, Dam overproduction does not impair bacterial growth Vibrio cholerae serotype O1
2.1.1.72 physiological function CcrM regulates the genes dnaA, ctrA, and ccrM at transcriptional level Caulobacter vibrioides
2.1.1.72 physiological function Dam methylation may control the expression of virulence genes Pasteurella multocida
2.1.1.72 physiological function DNA adenine methylation is involved in Aeromonas hydrophila pathogenesis Brucella abortus
2.1.1.72 physiological function DNA adenine methylation is involved in Aeromonas hydrophila pathogenesis Aeromonas hydrophila
2.1.1.72 physiological function the formation of 6-methyladenine reduces the thermodynamic stability of DNA and changes DNA curvature, as a consequence, the methylation state of specific adenosine moieties can affect DNA-protein interactions. Dam methylation regulates virulence genes at the posttranscriptional level Salmonella enterica
2.1.1.72 physiological function the formation of 6-methyladenine reduces the thermodynamic stability of DNA and changes DNA curvature, as a consequence, the methylation state of specific adenosine moieties can affect DNA-protein interactions. Dam methylation regulates virulence genes at the posttranscriptional level. Dam methylation plays a role in enterohemorrhagic Escherichia coli by controlling the production of the virulence factor Shiga toxin 2 Escherichia coli