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Literature summary extracted from

  • Singh, A.K.; Zhang, Y.M.; Zhu, K.; Subramanian, C.; Li, Z.; Jayaswal, R.K.; Gatto, C.; Rock, C.O.; Wilkinson, B.J.
    FabH selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes (2009), FEMS Microbiol. Lett., 301, 188-192.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.180 0.0053
-
 isovaleryl-CoA 30°C Listeria monocytogenes
2.3.1.180 0.0063
-
 2-methylbutyryl-CoA 10°C Listeria monocytogenes
2.3.1.180 0.011
-
 2-methylbutyryl-CoA 30°C Listeria monocytogenes
2.3.1.180 0.0169
-
 isovaleryl-CoA 10°C Listeria monocytogenes
2.3.1.180 0.0243
-
 isobutyryl-CoA 30°C Listeria monocytogenes
2.3.1.180 0.0307
-
 isobutyryl-CoA 10°C Listeria monocytogenes
2.3.1.180 0.0985
-
 acetyl-CoA 30°C Listeria monocytogenes

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.180 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] Listeria monocytogenes
-
 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] Listeria monocytogenes 10403S
-
 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Listeria monocytogenes
-
 acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Listeria monocytogenes 10403S
-
 acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 butyryl-CoA + malonyl-[acyl-carrier protein] Listeria monocytogenes
-
 3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 isobutyryl-CoA + malonyl-[acyl-carrier protein] Listeria monocytogenes
-
 3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 isovaleryl-CoA + malonyl-[acyl-carrier protein] Listeria monocytogenes
-
 3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 additional information Listeria monocytogenes beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria ?
-
 ?
2.3.1.180 additional information Listeria monocytogenes 10403S beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.180 Listeria monocytogenes C0LNR0 gene fabH
-
2.3.1.180 Listeria monocytogenes 10403S C0LNR0 gene fabH
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.180 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
-
 Listeria monocytogenes 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] 2-methylbutyryl-CoA is the preferred substrate Listeria monocytogenes 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein]
-
 Listeria monocytogenes 10403S 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 2-methylbutyryl-CoA + malonyl-[acyl-carrier protein] 2-methylbutyryl-CoA is the preferred substrate Listeria monocytogenes 10403S 3-oxo-4-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Listeria monocytogenes acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Listeria monocytogenes 10403S acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 butyryl-CoA + malonyl-[acyl-carrier protein]
-
 Listeria monocytogenes 3-oxohexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 isobutyryl-CoA + malonyl-[acyl-carrier protein]
-
 Listeria monocytogenes 3-oxo-4-methylpentanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 isovaleryl-CoA + malonyl-[acyl-carrier protein]
-
 Listeria monocytogenes 3-oxo-5-methylhexanoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 additional information beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria Listeria monocytogenes ?
-
 ?
2.3.1.180 additional information substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview Listeria monocytogenes ?
-
 ?
2.3.1.180 additional information beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria Listeria monocytogenes 10403S ?
-
 ?
2.3.1.180 additional information substrate specificity, FabH has a clear preference for branched-chain CoA precursors versus acetyl-CoA at 30°C, while this preference is not so pronounced at 10°C, overview Listeria monocytogenes 10403S ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 FabH
-
 Listeria monocytogenes

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.180 10 30 assay at Listeria monocytogenes

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.180 0.0007
-
 acetyl-CoA 30°C Listeria monocytogenes
2.3.1.180 0.018
-
 isovaleryl-CoA 10°C Listeria monocytogenes
2.3.1.180 0.102
-
 isobutyryl-CoA 10°C Listeria monocytogenes
2.3.1.180 0.105
-
 2-methylbutyryl-CoA 10°C Listeria monocytogenes
2.3.1.180 0.12
-
 isovaleryl-CoA 30°C Listeria monocytogenes
2.3.1.180 0.32
-
 isobutyryl-CoA 30°C Listeria monocytogenes
2.3.1.180 0.46
-
 2-methylbutyryl-CoA 30°C Listeria monocytogenes

General Information

EC Number General Information Comment Organism
2.3.1.180 metabolism beta-ketoacyl-acyl carrier protein synthase III, FabH, carries out first the first condensation reaction in fatty acid biosynthesis, which determines the type of fatty acid produced in bacteria Listeria monocytogenes

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.3.1.180 0.17
-
 acetyl-CoA 30°C Listeria monocytogenes
2.3.1.180 1.67
-
 isovaleryl-CoA 10°C Listeria monocytogenes
2.3.1.180 3.33
-
 isobutyryl-CoA 10°C Listeria monocytogenes
2.3.1.180 6.67
-
 2-methylbutyryl-CoA 10°C Listeria monocytogenes
2.3.1.180 13.3
-
 isobutyryl-CoA 30°C Listeria monocytogenes
2.3.1.180 23.3
-
 isovaleryl-CoA 30°C Listeria monocytogenes
2.3.1.180 41.7
-
 2-methylbutyryl-CoA 30°C Listeria monocytogenes