EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.12.99.6 | HydE | can coordinate variable amounts of Fe and sulfide | Thermotoga maritima | |
1.12.99.6 | HydE | is required to synthesize and assemble the active site utilizing Escherichia coli metabolites | Clostridium acetobutylicum | |
1.12.99.6 | HydEF | maturase, role in biosynthesis of the active site. HydEF and hydG, coexpressed with the structural genes hydA1 and hydA2 in Escherichia coli lead to active [FeFe]-hydrogenase | Chlamydomonas reinhardtii | |
1.12.99.6 | HydF | - |
Thermotoga maritima | |
1.12.99.6 | HydF | is required to synthesize and assemble the active site utilizing Escherichia coli metabolites | Clostridium acetobutylicum | |
1.12.99.6 | HydG | is required to synthesize and assemble the active site utilizing Escherichia coli metabolites | Clostridium acetobutylicum | |
1.12.99.6 | HydG | maturase, role in biosynthesis of the active site | Desulfovibrio vulgaris | |
1.12.99.6 | HydG | maturase, role in biosynthesis of the active site. HydEF and hydG, coexpressed with the structural genes hydA1 and hydA2 in Escherichia coli lead to active [FeFe]-hydrogenase | Chlamydomonas reinhardtii |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.12.99.6 | expressed in Escherichia coli | Desulfovibrio vulgaris |
1.12.99.6 | hydA1 and hydA2 expressed in Escherichia coli | Chlamydomonas reinhardtii |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.12.99.6 | Fe | lacks the ferredoxin-like clusters, but contains the H-cluster [Fe4S4] component | Chlamydomonas reinhardtii | |
1.12.99.6 | Fe | two ferredoxin-like [Fe4S4] clusters | Desulfovibrio vulgaris | |
1.12.99.6 | Fe | [FeS] cluster | Thermotoga maritima |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.12.99.6 | Chlamydomonas reinhardtii | - |
- |
- |
1.12.99.6 | Clostridium acetobutylicum | - |
- |
- |
1.12.99.6 | Desulfovibrio vulgaris | - |
- |
- |
1.12.99.6 | Thermotoga maritima | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.12.99.6 | HydA1 | - |
Chlamydomonas reinhardtii |
1.12.99.6 | HydA2 | - |
Chlamydomonas reinhardtii |
1.12.99.6 | [FeFe]-hydrogenase | - |
Chlamydomonas reinhardtii |
1.12.99.6 | [FeFe]-hydrogenase | - |
Clostridium acetobutylicum |
1.12.99.6 | [FeFe]-hydrogenase | - |
Desulfovibrio vulgaris |
1.12.99.6 | [FeFe]-hydrogenase | - |
Thermotoga maritima |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.12.99.6 | malfunction | heterologous expression of the two structural genes of [FeFe]-hydrogenase in Escherichia coli yields an inactive enzyme, only the two ferredoxin-like [Fe4S4] clusters are unambiguously assembled | Desulfovibrio vulgaris |