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Literature summary extracted from

  • Yu, D.M.; Yao, T.W.; Chowdhury, S.; Nadvi, N.A.; Osborne, B.; Church, W.B.; McCaughan, G.W.; Gorrell, M.D.
    The dipeptidyl peptidase IV family in cancer and cell biology (2010), FEBS J., 277, 1126-1144.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.14.5 medicine DPIV is a type 2 diabetes therapeutic target Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.14.5 sitagliptin
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.14.5 cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.14.5 glucagon-like peptide 1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.14.5 neuropeptide Y + H2O Homo sapiens
-
 ?
-
 ?
3.4.14.5 stromal cell-derived factor-1 + H2O Homo sapiens
-
 ?
-
 ?
3.4.14.5 Substance P + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.14.5 Homo sapiens P27487
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.14.5 B-cell chronic lymphocytic leukemia cell
-
 Homo sapiens
-
3.4.14.5 capillary endothelial cell
-
 Homo sapiens
-
3.4.14.5 endometrial adenocarcinoma cell
-
 Homo sapiens
-
3.4.14.5 epithelial cell
-
 Homo sapiens
-
3.4.14.5 esophageal cancer cell
-
 Homo sapiens
-
3.4.14.5 gut
-
 Homo sapiens
-
3.4.14.5 hepatocellular carcinoma cell
-
 Homo sapiens
-
3.4.14.5 kidney
-
 Homo sapiens
-
3.4.14.5 liver
-
 Homo sapiens
-
3.4.14.5 lung adenocarcinoma cell
-
 Homo sapiens
-
3.4.14.5 lymph node
-
 Homo sapiens
-
3.4.14.5 mucous gland acinar cells of mucous glands Homo sapiens
-
3.4.14.5 ovarian carcinoma cell
-
 Homo sapiens
-
3.4.14.5 pancreas
-
 Homo sapiens
-
3.4.14.5 prostate cancer cell
-
 Homo sapiens
-
3.4.14.5 salivary gland acinar cells of salivary glands Homo sapiens
-
3.4.14.5 spleen
-
 Homo sapiens
-
3.4.14.5 thymus
-
 Homo sapiens
-
3.4.14.5 thyroid carcinoma cell
-
 Homo sapiens
-
3.4.14.5 uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.14.5 glucagon-like peptide 1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 neuropeptide Y + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 stromal cell-derived factor-1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.5 Substance P + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.14.5 CD26
-
 Homo sapiens
3.4.14.5 dipeptidyl peptidase IV
-
 Homo sapiens
3.4.14.5 DPIV
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.14.5 Homo sapiens DPIV expression is progressively downregulated in endometrial adenocarcinoma down