EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.43 | apolipoprotein A-I | ApoA-I, required for activity, activation in inhibited by binding of haptoglobin | Homo sapiens | |
2.3.1.43 | apolipoprotein E | ApoE, stimulates the enzyme | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.43 | Haptoglobin | binds apolipoprotein A-I and E, via its Hpt beta-subunit, and impairs its stimulation of LCAT, mechanism, overview. The affinity of Hpt for ApoE is higher than that for ApoA-I. Hpt also impairs human hepatoblastoma-derived cell uptake of cholesterol from proteoliposomes containing ApoE or ApoA-I | Homo sapiens | |
2.3.1.43 | additional information | interaction between Hpt and ApoE represents a mechanism by which inflammation affects atherosclerosis progression | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.43 | extracellular | - |
Homo sapiens | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.43 | phosphatidylcholine + cholesterol | Homo sapiens | - |
cholesteryl ester + lysophosphatidylcholine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.43 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.43 | blood plasma | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.43 | phosphatidylcholine + cholesterol | - |
Homo sapiens | cholesteryl ester + lysophosphatidylcholine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.43 | LCAT | - |
Homo sapiens |
2.3.1.43 | lecithin:cholesterol acyltransferase | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.43 | physiological function | LCAT plays a major role in reverse cholesterol transport, RCT | Homo sapiens |