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Literature summary extracted from

  • Okuda, T.; Furukawa, K.; Nakayama, K.
    A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis (2009), FEBS J., 276, 5191-5202.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.228 cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.228 UDP-galactose + lactosylceramide Homo sapiens
-
 UDP + globotriaosylceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.228 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.228 endothelial cell
-
 Homo sapiens
-
2.4.1.228 HML-Gb3 cell
-
 Homo sapiens
-
2.4.1.228 HUVEC cell
-
 Homo sapiens
-
2.4.1.228 NCCIT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.228 UDP-galactose + lactosylceramide
-
 Homo sapiens UDP + globotriaosylceramide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.228 alpha1,4-galactosyltransferase
-
 Homo sapiens
2.4.1.228 GB3 synthase
-
 Homo sapiens
2.4.1.228 Gb3S
-
 Homo sapiens
2.4.1.228 globotriaosylceramide synthase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.4.1.228 Homo sapiens 10 mM 2-deoxy-D-glucose markedly reduces endogenous globotriaosylceramide synthase mRNA levels, can control globotriaosylceramide biosynthesis through the inhibition of globotriaosylceramide synthase transcription down