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Literature summary extracted from

  • Bera, S.; Wallimann, T.; Ray, S.; Ray, M.
    Enzymes of creatine biosynthesis, arginine and methionine metabolism in normal and malignant cells (2008), FEBS J., 275, 5899-5909.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.3.1 mitochondrion
-
 Mus musculus 5739
-
4.1.1.17 cytosol
-
 Mus musculus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.2 Mus musculus
-
-
-
2.1.1.13 Mus musculus
-
-
-
2.1.4.1 Mus musculus
-
-
-
3.5.3.1 Mus musculus
-
-
-
3.13.2.1 Mus musculus
-
-
-
4.1.1.17 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.2 blood
-
 Mus musculus
-
2.1.1.2 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
2.1.1.2 kidney
-
 Mus musculus
-
2.1.1.2 sarcoma cell S180 cells Mus musculus
-
2.1.1.2 skeletal muscle
-
 Mus musculus
-
2.1.1.13 blood
-
 Mus musculus
-
2.1.1.13 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
2.1.1.13 kidney
-
 Mus musculus
-
2.1.1.13 sarcoma cell S180 cells Mus musculus
-
2.1.1.13 skeletal muscle
-
 Mus musculus
-
2.1.4.1 blood
-
 Mus musculus
-
2.1.4.1 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
2.1.4.1 kidney
-
 Mus musculus
-
2.1.4.1 sarcoma cell S180 cells Mus musculus
-
2.1.4.1 skeletal muscle
-
 Mus musculus
-
3.5.3.1 blood
-
 Mus musculus
-
3.5.3.1 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
3.5.3.1 kidney
-
 Mus musculus
-
3.5.3.1 sarcoma cell S180 cells Mus musculus
-
3.5.3.1 skeletal muscle
-
 Mus musculus
-
3.13.2.1 blood
-
 Mus musculus
-
3.13.2.1 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
3.13.2.1 kidney
-
 Mus musculus
-
3.13.2.1 sarcoma cell S180 cells Mus musculus
-
3.13.2.1 skeletal muscle
-
 Mus musculus
-
4.1.1.17 blood
-
 Mus musculus
-
4.1.1.17 Ehrlich ascites carcinoma cell
-
 Mus musculus
-
4.1.1.17 kidney
-
 Mus musculus
-
4.1.1.17 sarcoma cell S180 cells Mus musculus
-
4.1.1.17 skeletal muscle
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1.1.2 0.0005
-
 liver of sarcoma-bearing mice Mus musculus
2.1.1.2 0.00053
-
 S180 cell Mus musculus
2.1.1.2 0.00057
-
 Ehrlich ascites carcinoma cell Mus musculus
2.1.1.2 0.0006
-
 liver of normal mice Mus musculus
2.1.1.2 0.0006
-
 sarcoma Mus musculus
2.1.4.1 0.0004
-
 Ehrlich ascites carcinoma cell Mus musculus
2.1.4.1 0.0004
-
 sarcoma Mus musculus
2.1.4.1 0.000485
-
 S180 cell Mus musculus
2.1.4.1 0.00097
-
 kidney of sarcoma-bearing mice Mus musculus
2.1.4.1 0.00099
-
 kidney of normal mice Mus musculus
3.5.3.1 0.0007
-
 Ehrlich ascites carcinoma cell Mus musculus
3.5.3.1 0.0008
-
 sarcoma Mus musculus
3.5.3.1 0.0012
-
 S180 cell Mus musculus
3.5.3.1 0.00316
-
 kidney of sarcoma-bearing mice Mus musculus
3.5.3.1 0.003175
-
 kidney of normal mice Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.2 S-adenosyl-L-methionine + guanidinoacetic acid + glutathione assay at pH 7.4, 37°C, 1 h, reaction stopped with 5% trichloroacetic acid Mus musculus ?
-
 ?
2.1.4.1 arginine + glycine assay at pH 7.4, 37°C Mus musculus ?
-
 ?
3.5.3.1 L-arginine + H2O assay at pH 7.4, 37°C Mus musculus L-ornithine + urea
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.2 GAMT
-
 Mus musculus
2.1.1.2 N-guanidinoacetate methyltransferase
-
 Mus musculus
2.1.1.13 methionine synthase
-
 Mus musculus
2.1.4.1 AGAT
-
 Mus musculus
2.1.4.1 L-arginine:glycine amidinotransferase
-
 Mus musculus
3.5.3.1 arginase II
-
 Mus musculus
3.5.3.1 mitochondrial arginase
-
 Mus musculus
3.13.2.1 S-adenosyl homocysteine hydrolase
-
 Mus musculus
3.13.2.1 SAH hydrolase
-
 Mus musculus
4.1.1.17 ODC
-
 Mus musculus
4.1.1.17 ornithine decarboxylase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.1.1.2 37
-
 assay at Mus musculus
2.1.4.1 37
-
 assay at Mus musculus
3.5.3.1 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.1.1.2 7.4
-
 assay at Mus musculus
2.1.4.1 7.4
-
 assay at Mus musculus
3.5.3.1 7.4
-
 assay at Mus musculus

Expression

EC Number Organism Comment Expression
2.1.1.2 Mus musculus high expression in tumor cells up
2.1.1.13 Mus musculus high expression in tumor cells up
2.1.4.1 Mus musculus high expression in malignant cells up
3.13.2.1 Mus musculus high expression in tumor cells up
4.1.1.17 Mus musculus high expression in tumor cells up

General Information

EC Number General Information Comment Organism
2.1.1.2 physiological function creatine synthesis Mus musculus
2.1.4.1 physiological function creatine synthesis Mus musculus