EC Number | Cloned (Comment) | Organism |
---|---|---|
1.13.11.33 | 15-LO-1 expressed in Sf 9 cells | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.13.11.33 | cytosol | main distribution | Homo sapiens | 5829 | - |
1.13.11.33 | membrane | the enzyme translocates to the membrane upon calcium challenge. In the presence of Ca2+/Mg2+, with or without calcium ionophore, the majority of 15-LO-1 is present in the membrane fraction | Homo sapiens | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.33 | Ca2+ | in the presence of Ca2+, with or without calcium ionophore, the majority of 15-LO-1 is found in the membrane fraction, although significant amounts are also detected in the supernatant fraction | Homo sapiens | |
1.13.11.33 | Mg2+ | in the presence of Mg2+, with or without calcium ionophore, the majority of 15-LO-1 is found in the membrane fraction, although significant amounts are also detected in the supernatant fraction | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.33 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.33 | eosinophil | - |
Homo sapiens | - |
1.13.11.33 | L-428 cell | - |
Homo sapiens | - |
1.13.11.33 | macrophage | - |
Homo sapiens | - |
1.13.11.33 | additional information | high expression in L-1236 cells (Hodgkin Reed-Sternberg cells), present in HDLM2 cells and KMH2 cells | Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.33 | arachidonate + O2 | - |
Homo sapiens | (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.33 | 15-lipoxygenase-1 | - |
Homo sapiens |
1.13.11.33 | 15-LO-1 | - |
Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.13.11.33 | physiological function | the expression of 15-lipoxygenase-1 and the putative formation of eoxins by Hodgkin Reed-Sternberg cells in vivo are likely to contribute to the inflammatory features of Hodgkin lymphoma | Homo sapiens |