Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dunn, R.V.; Marshall, K.R.; Munro, A.W.; Scrutton, N.S.
    The pH dependence of kinetic isotope effects in monoamine oxidase A indicates stabilization of the neutral amine in the enzyme-substrate complex (2008), FEBS J., 275, 3850-3858.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.4 MAO A, expression in Pichia pastoris strain KM17H Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 D-amphetamine competitive inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information determination of substrate-dependent steady-state and stopped flow kinetics, pH dependence, overview Homo sapiens
1.4.3.4 0.028
-
 kynuramine pH 9.0, 20°C, MAO A Homo sapiens
1.4.3.4 0.041
-
 kynuramine pH 7.5, 20°C, MAO A Homo sapiens
1.4.3.4 0.077
-
 benzylamine pH 8.5, 20°C, MAO A Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens P21397
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.4 recombinant MAO A from Pichia pastoris strain KM17H by anion exchange chromatography, ultrafiltration, and dialysis in presence of 20% glycerol and inhibitor D-amphetamine Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 benzylamine + H2O + O2 MAO-A Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 kynuramine + H2O + O2 MAO-A Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 phenylethylamine + H2O + O2 MAO-A Homo sapiens 2-phenylethanal + NH3 + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO A
-
 Homo sapiens
1.4.3.4 monoamine oxidase A
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.4.3.4 20
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.4.3.4 additional information
-
 pH dependence of steady-state kinetics, overview Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.4.3.4 6.5 9.5
-
 Homo sapiens