EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.15.6 | drug development | the vitamin D3 derivatives produced by the action of P450scc are good candidates for use in the therapy of hyperproliferative disorders | Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.14.15.6 | mitochondrion | - |
Bos taurus | 5739 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.15.6 | Bos taurus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.14.15.6 | - |
Bos taurus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.15.6 | adrenal cortex | - |
Bos taurus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.15.6 | 20,23-dihydroxyvitamin D3 + reduced adrenodoxin + O2 | - |
Bos taurus | 17alpha,20,23-trihydroxyvitamin D3 + oxidized adrenodoxin + H2O | - |
? | |
1.14.15.6 | 20-hydroxyvitamin D3 + reduced adrenodoxin + O2 | - |
Bos taurus | 20,23-dihydroxyvitamin D3 + 17alpha,20,23-trihydroxyvitamin D3 + oxidized adrenodoxin + H2O | - |
? | |
1.14.15.6 | vitamin D3 + reduced adrenodoxin + O2 | - |
Bos taurus | 20-hydroxyvitamin D3 + oxidized adrenodoxin + H2O | when incubated in 0.45% cyclodextrin, 20-hydroxyvitamin D3 is the major product of vitamin D3 metabolism by P450scc. The second major product is 20,23-dihydroxyvitamin D3. Major products dissociate from the P450scc active site and accumulate at a concentration well above the P450scc concentration | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.15.6 | CYP11A1 | - |
Bos taurus |
1.14.15.6 | cytochrome P450scc | - |
Bos taurus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.14.15.6 | adrenodoxin | - |
Bos taurus |