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Literature summary extracted from

  • Jackson, R.M.; Gupta, C.
    Hypoxia and kinase activity regulate lung epithelial cell glutathione (2010), Exp. Lung Res., 36, 45-56.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.2 additional information decrease of enzyme activity in hypoxia: 20% after 6 h, 17% after 12 h, 23% after 24 h, hypoxia-induced decrease in enzyme activity may be prevented by MAPK inhibition and catalase Homo sapiens
6.3.2.3 additional information decrease of enzyme activity in hypoxia: 20% after 6 h, 17% after 12 h, 23% after 24 h, hypoxia-induced decrease in enzyme activity may be prevented by MAPK inhibition and catalase Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.2 Homo sapiens
-
-
-
6.3.2.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.2 A-549 cell
-
 Homo sapiens
-
6.3.2.3 A-549 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.2 glutamate + ATP + L-cysteine assay at pH 8.2 Homo sapiens ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
6.3.2.3 glycine + ATP + gamma-L-glutamyl-L-cysteine assay at pH 8.2 Homo sapiens ADP + phosphate + glutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.2 GCL
-
 Homo sapiens
6.3.2.2 glutamate cysteine ligase
-
 Homo sapiens
6.3.2.3 Glutathione synthase
-
 Homo sapiens
6.3.2.3 GS
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.2.2 8.2
-
 assay at Homo sapiens
6.3.2.3 8.2
-
 assay at Homo sapiens