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Literature summary extracted from

  • Sanchez-Hidalgo, M.; de la Lastra, C.A.; Carrascosa-Salmoral, M.P.; Naranjo, M.C.; Gomez-Corvera, A.; Caballero, B.; Guerrero, J.M.
    Age-related changes in melatonin synthesis in rat extrapineal tissues (2009), Exp. Gerontol., 44, 328-334.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.4 heart
-
 Rattus norvegicus
-
2.1.1.4 kidney
-
 Rattus norvegicus
-
2.1.1.4 liver highest activity in liver Rattus norvegicus
-
2.1.1.4 spleen lowest activity in spleen Rattus norvegicus
-
2.1.1.4 thymus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.4 N-acetylserotonin + S-adenosyl-L-methionine
-
 Rattus norvegicus S-adenosyl-L-homocysteine + N-acetyl-5-methoxytryptamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.4 HIOMT
-
 Rattus norvegicus
2.1.1.4 hydroxyindole-O-methyltransferase
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
2.1.1.4 Rattus norvegicus there is an age-related decline in rat extrapineal melatonin synthesis with a consequent HIOMT functionality decrease in spleen, liver and heart during physiological aging, in the thymus HIOMT expression reveals no significant alterations with age down

General Information

EC Number General Information Comment Organism
2.1.1.4 metabolism HIOMT is a key enzyms involved in melatonin synthesis Rattus norvegicus