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Literature summary extracted from

  • Chang, Y.; Wang, S.J.
    Hypericin, the active component of St. Johns wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway (2010), Eur. J. Pharmacol., 634, 53-61.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.24 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD98059 Rattus norvegicus
2.7.11.24 hypericin hypericin-mediated inhibition of glutamate release appears to involve the suppression of mitogen-activated protein kinase pathway Rattus norvegicus
2.7.11.24 U0126
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.24 synaptosome
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.24 Ca2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.24 ATP + a protein Rattus norvegicus
-
 ADP + a phosphoprotein
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.24 Rattus norvegicus
-
 Sprague-Dawley rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.24 cerebral cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.24 ATP + a protein
-
 Rattus norvegicus ADP + a phosphoprotein
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.24 MAP kinase
-
 Rattus norvegicus
2.7.11.24 mitogen-activated kinase
-
 Rattus norvegicus
2.7.11.24 mitogen-activated protein kinase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.24 ATP
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
2.7.11.24 physiological function the mitogen-activated protein kinase signaling pathway is one of the major second messenger systems regulating glutamate release at the presynaptic level Rattus norvegicus