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Literature summary extracted from

  • James, M.O.; Sacco, J.C.; Faux, L.R.
    Effects of food natural products on the biotransformation of PCBs (2008), Environ. Toxicol. Pharmacol., 25, 211-217.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.1 additional information SULT1A1 and SULT1A3 are potently inhibited by natural products present in juices, apple, grape, grapefruit, green and black teas, and coffee Homo sapiens
2.8.2.1 quercetin found in many fruits, vegetables and wine, is a potent inhibitor of the sulfation of 4-nitrophenol, estradiol, and several drug substrates in human liver cytosol and with recombinantly expressed human SULT1A1 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.1 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.1 additional information Homo sapiens the enzyme is active in conjugating the polychlorobiphenyl alcohols, e.g. 3'-OH-trichlorobiphenyl, 4'-OH-trichlorobiphenyl and 4'-OH-(chlorobiphenyl)112, SULT2A1 is active with 4-OH-(chlorobiphenyl)34 and 4'-OH-(chlorobiphenyl)68, but not with 4'-OH-nonachlorobiphenyl ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.1 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.1 additional information the enzyme is active in conjugating the polychlorobiphenyl alcohols, e.g. 3'-OH-trichlorobiphenyl, 4'-OH-trichlorobiphenyl and 4'-OH-(chlorobiphenyl)112, SULT2A1 is active with 4-OH-(chlorobiphenyl)34 and 4'-OH-(chlorobiphenyl)68, but not with 4'-OH-nonachlorobiphenyl Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.1 PAPS-sulfotransferase
-
 Homo sapiens
2.8.2.1 SULT
-
 Homo sapiens
2.8.2.1 SULT1A1
-
 Homo sapiens
2.8.2.1 SULT1A3
-
 Homo sapiens
2.8.2.1 SULT1E1
-
 Homo sapiens
2.8.2.1 SULT2A1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.8.2.1 0.001
-
 below, SULT1A1 Homo sapiens quercetin
2.8.2.1 0.001
-
 SULT1E1 Homo sapiens quercetin
2.8.2.1 0.064
-
 SULT2A1 Homo sapiens quercetin

General Information

EC Number General Information Comment Organism
2.8.2.1 metabolism sulfonation, catalyzed by PAPS-sulfotransferases, especially SULT2A1,is one major phase II pathways for polychlorobiphenylols conjugation and for elimination of the potentially toxic compounds, overview Homo sapiens