Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ardehali, M.B.; Yao, J.; Adelman, K.; Fuda, N.J.; Petesch, S.J.; Webb, W.W.; Lis, J.T.
    Spt6 enhances the elongation rate of RNA polymerase II in vivo (2009), EMBO J., 28, 1067-1077.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.6 additional information the enzyme complex requires multiple transcription factors and protein interactions for activity, e.g. Spt6, overview Drosophila melanogaster
2.7.7.6 Spt6 transcription factor, Pol II shows a broad requirement for essential Spt6 during different stages of development, e.g. for for maximal recruitment of Paf1 and Spt5 to transcriptionally active Hsp70. Spt6 interacts with both nucleosome structure and Pol II, it has a role in elongation, directed RNAi knock-down of Spt6 reduces the elongation rate, the Spt6-dependent effect on elongation rate persists during steady-state-induced transcription, reducing the elongation rate from about 1100 to 500 bp/min. Stimulation of Pol II elongation rate by Spt6 is not mediated through transcription factor TFIIS Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.6 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.6 S2 cell
-
Drosophila melanogaster
-
2.7.7.6 salivary gland
-
Drosophila melanogaster
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.6 Pol II
-
Drosophila melanogaster
2.7.7.6 RNA polymerase II
-
Drosophila melanogaster