BRENDA - Enzyme Database show

Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK)

Kim, S.R.; Saito, Y.; Maekawa, K.; Sugiyama, E.; Kaniwa, N.; Ueno, H.; Okusaka, T.; Ikeda, M.; Morizane, C.; Yamamoto, N.; Yoshida, T.; Kamatani, N.; Furuse, J.; Ishii, H.; Saijo, N.; Ozawa, S.; Sawada, J.; Drug Metab. Pharmacokinet. 23, 379-384 (2008)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
2.7.1.74
P122S
the mutant shows reduced enzyme activity
Homo sapiens
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.74
Homo sapiens
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
703425
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + cytarabine
-
703425
Homo sapiens
ADP + cytarabine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + gemcitabine
-
703425
Homo sapiens
ADP + gemcitabine 5'-phosphate
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.74
ATP
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
2.7.1.74
P122S
the mutant shows reduced enzyme activity
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.74
ATP + 2'-deoxycytidine
-
703425
Homo sapiens
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + cytarabine
-
703425
Homo sapiens
ADP + cytarabine 5'-phosphate
-
-
-
?
2.7.1.74
ATP + gemcitabine
-
703425
Homo sapiens
ADP + gemcitabine 5'-phosphate
-
-
-
?