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Literature summary extracted from

  • Huber, W.J.; Marohnic, C.C.; Peters, M.; Alam, J.; Reed, J.R.; Masters, B.S.; Backes, W.L.
    Measurement of membrane-bound human heme oxygenase-1 activity using a chemically defined assay system (2009), Drug Metab. Dispos., 37, 857-864.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.18 additional information a higher dilauroylphosphatidylcholine/HO-1 ratio than typically used provides an improved environment for HO-1 activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.18
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.18 R254K enhances protein stability during the glutathione S-transferase-tag removal procedure involving the protease thrombin Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.18 additional information HO-1-generated hydrogen peroxide leads to a decrease in HO-1 activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.18 membrane presence of the membrane-spanning region on HO-1 is required for efficient membrane incorporation, which is achieved after a 2 h preincubation period at room temperature Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.18 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.18
-
 Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.14.14.18 -80°C Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.18 heme + electron donor + O2
-
 Homo sapiens biliverdin + Fe2+ + CO + oxidized electron donor + H2O
-
 ?
1.14.14.18 additional information ability of uncoupled HO-1 to produce large quantities of H2O2, H2O2 generation is much more efficient with the full-length form of HO-1 than with the soluble form Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.18 heme oxygenase-1
-
 Homo sapiens
1.14.14.18 HO-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.18 heme
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.18 physiological function because HO-1 and NADPH-cytochrome P450 reductase (CPR) are membrane-bound proteins, the presence of membrane hydrophobic milieu (dilauroylphosphatidylcholine or endoplasmic reticulum membrane) may alter the mechanism by which cytosolic biliverdin reductase metabolizes its substrate biliverdin to bilirubin Homo sapiens