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Literature summary extracted from

  • Itaeaho, K.; Court, M.H.; Uutela, P.; Kostiainen, R.; Radominska-Pandya, A.; Finel, M.
    Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10 (2009), Drug Metab. Dispos., 37, 768-775.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.17 F90A mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity Homo sapiens
2.4.1.17 F90L mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity Homo sapiens
2.4.1.17 F93A mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity Homo sapiens
2.4.1.17 F93L mutation in isoform 1A10, decrease in dopamine glucuronidation, no decrease in substrate affinity. Mutant conjugates dopamine at the 4-hydroxyl postion 4 times more efficiently than at the 3-OH position Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 1.89
-
 dopamine formation of dopamine-4-O-glucuronide, mutant F90A Homo sapiens
2.4.1.17 1.95
-
 dopamine formation of dopamine-4-O-glucuronide, wild-type Homo sapiens
2.4.1.17 1.99
-
 dopamine formation of dopamine-3-O-glucuronide, mutant F90A Homo sapiens
2.4.1.17 2.19
-
 dopamine formation of dopamine-3-O-glucuronide, wild-type Homo sapiens
2.4.1.17 2.31
-
 dopamine formation of dopamine-3-O-glucuronide, mutant F90L Homo sapiens
2.4.1.17 2.59
-
 dopamine formation of dopamine-4-O-glucuronide, mutant F90L Homo sapiens
2.4.1.17 2.63
-
 dopamine formation of dopamine-4-O-glucuronide, mutant F93A Homo sapiens
2.4.1.17 2.67
-
 dopamine formation of dopamine-3-O-glucuronide, mutant F93L Homo sapiens
2.4.1.17 2.91
-
 dopamine formation of dopamine-3-O-glucuronide, mutant F93A Homo sapiens
2.4.1.17 3.11
-
 dopamine formation of dopamine-4-O-glucuronide, mutant F93L Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 isoform UGT1A10
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 adipose tissue main expression in small intestine, colon, and adipose tissue Homo sapiens
-
2.4.1.17 colon main expression in small intestine, colon, and adipose tissue Homo sapiens
-
2.4.1.17 liver low expression, activity in intestinal microsomes is markedly higher than in liver microsomes Homo sapiens
-
2.4.1.17 additional information no expression in brain Homo sapiens
-
2.4.1.17 small intestine main expression in small intestine, colon, and adipose tissue. Activity in intestinal microsomes is markedly higher than in liver microsomes Homo sapiens
-
2.4.1.17 stomach low expression Homo sapiens
-
2.4.1.17 testis low expression Homo sapiens
-
2.4.1.17 trachea low expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-alpha-D-glucuronate + dopamine substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested Homo sapiens UDP + dopamine 3-O-beta-D-glucopyranosiduronic acid
-
 ?
2.4.1.17 UDP-alpha-D-glucuronate + dopamine
-
 Homo sapiens UDP + dopamine 4-O-beta-D-glucopyranosiduronic acid substrate for isoform UGT1A10, no substrate for all other UGT enzymes tested ?