Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Zhao, Z.; He, X.; Bi, Y.; Xia, Y.; Tao, N.; Li, L.; Ma, Q.
    Induction of CYP4F3 by benzene metabolites in human white blood cells in vivo in human promyelocytic leukemic cell lines and ex vivo in human blood neutrophils (2009), Drug Metab. Dispos., 37, 282-291.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.14.94 all-trans retinoic acid significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured HL-60 cells Homo sapiens
1.14.14.94 Benzene induces CYP4F3 in human blood cells both in vivo and in vitro Homo sapiens
1.14.14.94 phenol significantly induces expression of CYP4F3A at both mRNA and protein levels in cultured and differentiated HL-60 cells, in the proerythroid cell line K-562, and ex vivo in human neutrophils Homo sapiens

Application

EC Number Application Comment Organism
1.14.14.94 additional information induction of CYP4F3 may play a role in the development of benzene hematotoxicity and serve as a biomarker of benzene exposure Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.94 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.94 HL-60 cell promyelocytic leukemic cell line Homo sapiens
-
1.14.14.94 K-562 cell
-
 Homo sapiens
-
1.14.14.94 leukocyte
-
 Homo sapiens
-
1.14.14.94 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.94 leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.94 CYP4F3
-
 Homo sapiens
1.14.14.94 leukotriene B4 omega-hydroxylase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.94 physiological function is critical in the inactivation of leukotriene B4 in polymorphonuclear leukocytes with a -fold induction between 3 and 71 Homo sapiens