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Literature summary extracted from

  • Guo, J.; Liu, A.; Cao, H.; Luo, Y.; Pezzuto, J.M.; van Breemen, R.B.
    Biotransformation of the chemopreventive agent 2,4,4-trihydroxychalcone (isoliquiritigenin) by UDP-glucuronosyltransferases (2008), Drug Metab. Dispos., 36, 2104-2112.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.1.17 pharmacology based on the in vitro determination of a 25.3 min half-life for 2',4,4'-trihydroxychalcone when incubated with human liver microsomes, the intrinsic clearance of isoliquiritigenin was estimated to be 36.4 ml/min/kg Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 0.00298
-
 2',4,4'-trihydroxychalcone isoform UGT1A1, product 2',4,4'-trihydroxychalcone 2'-O-glucoside Homo sapiens
2.4.1.17 0.00315
-
 2',4,4'-trihydroxychalcone isoform UGT1A9, product 2',4,4'-trihydroxychalcone 4'-O-glucoside Homo sapiens
2.4.1.17 0.0043
-
 2',4,4'-trihydroxychalcone isoform UGT1A1, product 2',4,4'-trihydroxychalcone 4'-O-glucoside Homo sapiens
2.4.1.17 0.0258
-
 2',4,4'-trihydroxychalcone isoform UGT1A10, product 2',4,4'-trihydroxychalcone 2'-O-glucoside Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 hepatocyte
-
 Homo sapiens
-
2.4.1.17 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 2',4,4'-trihydroxychalcone + UDP-glucuronate i.e. isoliquiritigenin Homo sapiens UDP + 2',4,4'-trihydroxychalcone 4'-O-glucoside + 2',4,4'-trihydroxychalcone 2'-O-glucoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UGT1A1
-
 Homo sapiens
2.4.1.17 UGT1A10
-
 Homo sapiens
2.4.1.17 UGT1A9
-
 Homo sapiens