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Literature summary extracted from

  • Kelly, M.; Gauthier, M.S.; Saha, A.K.; Ruderman, N.B.
    Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization (2009), Diabetes, 58, 1953-1960.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.31 interleukin-6 directly activates AMPK in vivo and in vitro. Activates AMPK in skeletal muscle by increasing the concentration of cAMP and the AMP:ATP ratio. AMPK activation coincides temporally with a nearly 3fold increase in the AMP:ATP ratio in the extensor digitorum longus Rattus norvegicus
2.7.11.31 isoproterenol
-
 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.31 2'5'-dideoxyadenosine inhibits ability of interleukin-6 to activate AMPK Rattus norvegicus
2.7.11.31 propranolol effects of interleukin-6 on both AMPK activity and energy state are inhibited by coincubation with propranolol, suggesting involvement of beta-adrenergic signaling Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.31 Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.31 extensor digitorum longus
-
 Rattus norvegicus
-
2.7.11.31 gastrocnemius
-
 Rattus norvegicus
-
2.7.11.31 myotube
-
 Rattus norvegicus
-
2.7.11.31 skeletal muscle
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
2.7.11.31 AMP-activated protein kinase
-
 Rattus norvegicus
2.7.11.31 AMPK
-
 Rattus norvegicus