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Literature summary extracted from

  • Lin, Y.R.; Reddy, B.V.; Irvine, K.D.
    Requirement for a core 1 galactosyltransferase in the Drosophila nervous system (2008), Dev. Dyn., 237, 3703-3714.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.122 cloning of the C-terminal catalytic domain (amino acids 44-388) of C2GalTA into the vector pMT(1B) and transfected into S2 cells Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.122 additional information Drosophila melanogaster enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.122 Drosophila melanogaster Q7JRF9 isoform A
-
2.4.1.122 Drosophila melanogaster Q7K237
-
-
2.4.1.122 Drosophila melanogaster Q7K509 isoform B
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.122 amnioserosa in embryo Drosophila melanogaster
-
2.4.1.122 central nervous system in embryo Drosophila melanogaster
-
2.4.1.122 embryo
-
 Drosophila melanogaster
-
2.4.1.122 gut in larvae Drosophila melanogaster
-
2.4.1.122 imago in larvae Drosophila melanogaster
-
2.4.1.122 larva
-
 Drosophila melanogaster
-
2.4.1.122 nervous system in larvae Drosophila melanogaster
-
2.4.1.122 salivary gland
-
 Drosophila melanogaster
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.122 additional information
-
 C1GalTA exhibits high activity on Tn and glycopeptide substrates, although it also exhibits weaker activity on glycolipids Drosophila melanogaster

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.122 additional information enzyme elongates O-GalNAc by adding galactose in a beta1,3 linkage Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.122 C1GalTA
-
 Drosophila melanogaster
2.4.1.122 core 1 galactosyltransferase A
-
 Drosophila melanogaster
2.4.1.122 core 1 GalT
-
 Drosophila melanogaster
2.4.1.122 galactosyltransferase
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.4.1.122 malfunction C1GalTA null mutant is lethal, mutant animals exhibit a striking morphogenetic defect in which the ventral nerve cord is greatly elongated and the brain hemispheres are misshapen Drosophila melanogaster
2.4.1.122 physiological function C1GalTA is required for nervous system morphogenesis, C1GalTA is required for laminin O-glycosylation Drosophila melanogaster