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Literature summary extracted from

  • Gisbert, J.
    Role of monitoring thiopurine methyltransferase (TPMT) activity in the individualized therapy with azathioprine or 6-mercaptopurine (2008), Curr. Pharmacogenomics Person. Med., 6, 33-44.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 5-Aminosalicylate
-
 Homo sapiens
2.1.1.67 sulfasalazine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine Homo sapiens
-
 S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 thiopurine methyltransferase
-
 Homo sapiens
2.1.1.67 TPMT
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.1.1.67 Homo sapiens azathioprine therapy can raise TPMT activity up