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Literature summary extracted from

  • Low, D.; Casadesus, J.
    Clocks and switches: bacterial gene regulation by DNA adenine methylation (2008), Curr. Opin. Microbiol., 11, 106-112.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Escherichia coli the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Yersinia pseudotuberculosis the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Salmonella enterica the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine Caulobacter vibrioides the target sequence is 5'GATC3' S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.72 Caulobacter vibrioides
-
-
-
2.1.1.72 Escherichia coli
-
-
-
2.1.1.72 Salmonella enterica
-
-
-
2.1.1.72 Yersinia pseudotuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Escherichia coli S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Yersinia pseudotuberculosis S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Salmonella enterica S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?
2.1.1.72 S-adenosyl-L-methionine + DNA adenine the target sequence is 5'GATC3' Caulobacter vibrioides S-adenosyl-L-homocysteine + DNA 6-methyladenine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.72 Dam
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 Escherichia coli
2.1.1.72 Dam
-
 Yersinia pseudotuberculosis
2.1.1.72 Dam
-
 Salmonella enterica
2.1.1.72 Dam
-
 Caulobacter vibrioides
2.1.1.72 Dam methylase
-
 Escherichia coli
2.1.1.72 Dam methylase
-
 Yersinia pseudotuberculosis
2.1.1.72 Dam methylase
-
 Salmonella enterica
2.1.1.72 Dam methylase
-
 Caulobacter vibrioides
2.1.1.72 DNA adenine methyltransferase
-
 Escherichia coli
2.1.1.72 DNA adenine methyltransferase
-
 Yersinia pseudotuberculosis
2.1.1.72 DNA adenine methyltransferase
-
 Salmonella enterica
2.1.1.72 DNA adenine methyltransferase
-
 Caulobacter vibrioides

General Information

EC Number General Information Comment Organism
2.1.1.72 physiological function Dam methylation of finP prevents repression by H-NS,methlation of traJ leads to activation of Lrp binding to the traJ UAS by strand-specific hemimethylation Salmonella enterica
2.1.1.72 physiological function synthesis of P pili (pyelonephritis-associated protein) is subjected to phase variation and switching between On and Off states is controlled by Dam methylation, Dam methylation inhibits OxyR binding in the On state, Dam methylation of the upstream GATC site in agn43 increases transcription initiation, which occurs precisely at the G nucleotide of the GATC, finP transcription is activated by Dam methylation, Dam methylation does not regulate tir gene transcription nor tir mRNA stability Escherichia coli
2.1.1.72 physiological function transcriptional inhibition by hemimethylation of genes dnaA, ccrM, and ctrA Caulobacter vibrioides