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Literature summary extracted from

  • Zhan, Y.; Yu, H.; Yan, Y.; Ping, S.; Lu, W.; Zhang, W.; Chen, M.; Lin, M.
    Benzoate catabolite repression of the phenol degradation in Acinetobacter calcoaceticus PHEA-2 (2009), Curr. Microbiol., 59, 368-373.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.7 additional information benzoate causes transcriptional repression of phenol utilization by transcriptional inhibition of the mph operon. MphR encoding the transcriptional activator and mphN encoding the largest subunit of multi-component phenol hydroxylase in the benA mutant are significantly downregulated (about 7- and 70fold) on the basis of mRNA levels when benzoate is added to the medium Acinetobacter calcoaceticus

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.7 Acinetobacter calcoaceticus
-
strains PHEA-2 or PHEA-12
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.7 phenol + NAD(P)H + H+ + O2
-
Acinetobacter calcoaceticus catechol + NAD(P)+ + H2O
-
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Synonyms

EC Number Synonyms Comment Organism
1.14.13.7 MphN
-
Acinetobacter calcoaceticus
1.14.13.7 multi-component phenol hydroxylase
-
Acinetobacter calcoaceticus

Expression

EC Number Organism Comment Expression
1.14.13.7 Acinetobacter calcoaceticus expression of mphN encoding the largest subunit of multi-component phenol hydroxylase is reduced 70fold in the presence of both phenol and benzoate. Repression of mphN transcription is specifically released in the presence of benzoate down